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    SESN1 sestrin 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 481956, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SESN1provided by VGNC
    Official Full Name
    sestrin 1provided by VGNC
    Primary source
    VGNC:VGNC:46047
    See related
    Ensembl:ENSCAFG00845009981
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SESN1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (66840480..66939046, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (65777446..65875811, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (66311345..66409780, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (66191015..66289363, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (66039317..66137542, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 2 Neighboring gene uncharacterized LOC111098388 Neighboring gene uncharacterized LOC111098386 Neighboring gene uncharacterized LOC111098391 Neighboring gene centrosomal protein 57 like 1 Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene uncharacterized LOC612235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sestrin-1
    XP_038348500.1
    XP_038348501.1
    XP_038410813.1
    XP_038410814.1
    XP_038474687.1
    XP_038474689.1
    XP_038540249.1
    XP_038540250.1
    XP_539077.2
    XP_854341.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      66840480..66939046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038684321.1 → XP_038540249.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
      Related
      ENSCAFP00845013669.1, ENSCAFT00845017560.1
      Conserved Domains (1) summary
      pfam04636
      Location:107 → 551
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_038684322.1 → XP_038540250.1  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      66191015..66289363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492572.1 → XP_038348500.1  sestrin-1 isoform X1

      Conserved Domains (1) summary
      pfam04636
      Location:107 → 551
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_038492573.1 → XP_038348501.1  sestrin-1 isoform X2

      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      66039317..66137542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618759.1 → XP_038474687.1  sestrin-1 isoform X1

      Conserved Domains (1) summary
      pfam04636
      Location:107 → 551
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_038618761.1 → XP_038474689.1  sestrin-1 isoform X2

      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      66311345..66409780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554885.1 → XP_038410813.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
      Conserved Domains (1) summary
      pfam04636
      Location:107 → 551
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_038554886.1 → XP_038410814.1  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      65777446..65875811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_849248.6 → XP_854341.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R3A7, A0A8C0S7I6, A0A8C0S8D1, A0A8I3NDQ5, A0A8I3NPY4
      Conserved Domains (1) summary
      pfam04636
      Location:107 → 551
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_539077.6 → XP_539077.2  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0KZN5, A0A8C0N521, A0A8P0P2T2
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 491
      PA26; PA26 p53-induced protein (sestrin)
    Nucleotide Protein
    Heading Accession and Version

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