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    TNC tenascin C [ Canis lupus familiaris (dog) ]

    Gene ID: 481689, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TNCprovided by VGNC
    Official Full Name
    tenascin Cprovided by VGNC
    Primary source
    VGNC:VGNC:47646
    See related
    Ensembl:ENSCAFG00845010582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TNC in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (70201293..70293471, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (67478996..67543867, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (69487404..69552684, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (68715128..68780124, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (68756416..68820385, complement)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097961 Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC119874050 Neighboring gene uncharacterized LOC111097962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The appearance of stromal myofibroblasts and expression of Tn-C were significantly correlated with higher histological grades of malignancy and vascular/lymphatic invasion in simple carcinomas.
      Title: Increased presence of stromal myofibroblasts and tenascin-C with malignant progression in canine mammary tumors.
    2. This study reported the distribution of tenascin-C (TN-C) and the correlation of TN-C with the necro-inflammatory activity and expression of alpha-smooth muscle actin (alpha-SMA), cytokeratin 7 (CK7), and CD3+ T-lymphocytes in canine chronic hepatitis.
      Title: Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tenascin
    Names
    tenascin C (hexabrachion)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195149.2 → NP_001182078.1  tenascin precursor

      See identical proteins and their annotated locations for NP_001182078.1

      Status: VALIDATED

      Source sequence(s)
      JAAUVH010000356
      UniProtKB/TrEMBL
      A0A8C0S0B7, A0A8I3NF05, A0A8P0N6C4
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1980 → 2189
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      70201293..70293471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680968.1 → XP_038536896.1  tenascin isoform X3

      UniProtKB/TrEMBL
      A0A8I3NSD6, A0A8I3RW59, A0A8P0T564, A0A8P0T8Y3
      Related
      ENSCAFP00845015125.1, ENSCAFT00845019345.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:2072 → 2281
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    2. XM_038680969.1 → XP_038536897.1  tenascin isoform X4

      UniProtKB/TrEMBL
      A0A8C0K0T0
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:2072 → 2281
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    3. XM_038680967.1 → XP_038536895.1  tenascin isoform X2

      UniProtKB/TrEMBL
      A0A8C0QW02, A0A8I3NJF5, A0A8P0PAV3
      Related
      ENSCAFP00845015280.1, ENSCAFT00845019542.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:2072 → 2281
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    4. XM_038680970.1 → XP_038536898.1  tenascin isoform X5

      UniProtKB/TrEMBL
      A0A8C0S0B7, A0A8I3NJZ1, A0A8P0P622
      Related
      ENSCAFP00845015535.1, ENSCAFT00845019842.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:2071 → 2280
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    5. XM_038680966.1 → XP_038536894.1  tenascin isoform X1

      UniProtKB/TrEMBL
      A0A8I3NFV4, A0A8I3NSD6, A0A8P0NNH6, A0A8P0T564
      Related
      ENSCAFP00845014708.1, ENSCAFT00845018837.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:2163 → 2372
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    6. XM_038680971.1 → XP_038536899.1  tenascin isoform X6

      UniProtKB/TrEMBL
      A0A8I3NSD6, A0A8I3RWE2, A0A8P0T564, A0A8P0TA02
      Related
      ENSCAFP00845015647.1, ENSCAFT00845019976.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1981 → 2190
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    7. XM_038680975.1 → XP_038536903.1  tenascin isoform X10

      UniProtKB/TrEMBL
      A0A8C0JZF4
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1889 → 2098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    8. XM_038680974.1 → XP_038536902.1  tenascin isoform X9

      UniProtKB/TrEMBL
      A0A8C0S0B7
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1889 → 2098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    9. XM_038680972.1 → XP_038536900.1  tenascin isoform X7

      UniProtKB/TrEMBL
      A0A8C0S0B7, A0A8I3NF05, A0A8P0N6C4
      Related
      ENSCAFP00845015785.1, ENSCAFT00845020137.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1980 → 2189
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    10. XM_038680977.1 → XP_038536905.1  tenascin isoform X12

      UniProtKB/TrEMBL
      A0A8C0QFG8
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1798 → 2007
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    11. XM_038680973.1 → XP_038536901.1  tenascin isoform X8

      UniProtKB/TrEMBL
      A0A8C0S0B7, A0A8I3N9I4, A0A8P0SZZ7
      Related
      ENSCAFP00845016018.1, ENSCAFT00845020437.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1889 → 2098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    12. XM_038680978.1 → XP_038536906.1  tenascin isoform X13

      UniProtKB/TrEMBL
      A0A8C0QKQ6
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1708 → 1917
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    13. XM_038680976.1 → XP_038536904.1  tenascin isoform X11

      UniProtKB/TrEMBL
      A0A8C0JZC9, A0A8I3NDY9, A0A8P0NWD3
      Related
      ENSCAFP00845016089.1, ENSCAFT00845020520.1
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1798 → 2007
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    14. XM_038680979.1 → XP_038536907.1  tenascin isoform X14

      UniProtKB/TrEMBL
      A0A8C0QKQ6
      Conserved Domains (5) summary
      cd00063
      Location:624 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam18720
      Location:190 → 217
      EGF_Tenascin; Tenascin EGF domain
      pfam00041
      Location:894 → 976
      fn3; Fibronectin type III domain
      pfam00147
      Location:1525 → 1734
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      NF033759
      Location:301 → 611
      exchanger_TraA; outer membrane exchange protein TraA

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      68715128..68780124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      68756416..68820385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      69487404..69552684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      67478996..67543867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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