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    CASK calcium/calmodulin dependent serine protein kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 480887, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CASKprovided by VGNC
    Official Full Name
    calcium/calmodulin dependent serine protein kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:38729
    See related
    Ensembl:ENSCAFG00845025610
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CASK in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (35992809..36371502, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (23287445..23579098, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (36082753..36433406, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (36067274..36417597, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (36039464..36395455, complement)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC491837 Neighboring gene nyctalopin Neighboring gene G protein-coupled receptor 34 Neighboring gene G protein-coupled receptor 82 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106558482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia. Porter AP, et al. J Cell Sci, 2019 Jul 15. PMID 31289196, Free PMC Article
    2. The structural evolution of a P2Y-like G-protein-coupled receptor. Schulz A, et al. J Biol Chem, 2003 Sep 12. PMID 12835326

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results establish the importance of the CASK-Dlg1 interaction in oriented cell division and epithelial integrity.
      Title: The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peripheral plasma membrane protein CASK
    Names
    G-protein-coupled receptor GPR34
    XP_038305728.1
    XP_038305730.1
    XP_038305731.1
    XP_038305732.1
    XP_038320708.1
    XP_038379174.1
    XP_038379175.1
    XP_038379176.1
    XP_038379177.1
    XP_038379178.1
    XP_038379179.1
    XP_038379180.1
    XP_038379181.1
    XP_038379182.1
    XP_038379183.1
    XP_038379184.1
    XP_038379185.1
    XP_038443137.1
    XP_038443138.1
    XP_038443139.1
    XP_038443140.1
    XP_038443141.1
    XP_038443142.1
    XP_038443143.1
    XP_038443144.1
    XP_038443146.1
    XP_038443147.1
    XP_038443148.1
    XP_038443149.1
    XP_038507653.1
    XP_038507655.1
    XP_038507656.1
    XP_038507657.1
    XP_038507658.1
    XP_038507659.1
    XP_038507660.1
    XP_038507661.1
    XP_038507662.1
    XP_038507663.1
    XP_038507664.1
    XP_038507665.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      35992809..36371502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038449802.1 → XP_038305730.1  peripheral plasma membrane protein CASK isoform X2

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Related
      ENSCAFP00845036809.1, ENSCAFT00845046925.1
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:733 → 906
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    2. XM_038449803.1 → XP_038305731.1  peripheral plasma membrane protein CASK isoform X3

      UniProtKB/TrEMBL
      A0A8C0NDJ2
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:710 → 883
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    3. XM_038449800.1 → XP_038305728.1  peripheral plasma membrane protein CASK isoform X1

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Related
      ENSCAFP00845036144.1, ENSCAFT00845046038.1
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    4. XM_038449804.1 → XP_038305732.1  peripheral plasma membrane protein CASK isoform X4

      UniProtKB/TrEMBL
      A0A8P0NQ62
      Related
      ENSCAFP00845036576.1, ENSCAFT00845046589.1
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      36067274..36417597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038523247.1 → XP_038379175.1  peripheral plasma membrane protein CASK isoform X6

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:739 → 912
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    2. XM_038523256.1 → XP_038379184.1  peripheral plasma membrane protein CASK isoform X11

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    3. XM_038523253.1 → XP_038379181.1  peripheral plasma membrane protein CASK isoform X10

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:599 → 660
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:721 → 894
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    4. XM_038523252.1 → XP_038379180.1  peripheral plasma membrane protein CASK isoform X9

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    5. XM_038523246.1 → XP_038379174.1  peripheral plasma membrane protein CASK isoform X5

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:744 → 917
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    6. XM_038523249.1 → XP_038379177.1  peripheral plasma membrane protein CASK isoform X7

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    7. XM_038523248.1 → XP_038379176.1  peripheral plasma membrane protein CASK isoform X1

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    8. XM_038523257.1 → XP_038379185.1  peripheral plasma membrane protein CASK isoform X12

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:575 → 636
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:692 → 865
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    9. XM_038523251.1 → XP_038379179.1  peripheral plasma membrane protein CASK isoform X8

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    10. XM_038523255.1 → XP_038379183.1  peripheral plasma membrane protein CASK isoform X4

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    11. XM_038523254.1 → XP_038379182.1  peripheral plasma membrane protein CASK isoform X3

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:710 → 883
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    12. XM_038523250.1 → XP_038379178.1  peripheral plasma membrane protein CASK isoform X2

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:733 → 906
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      36039464..36395455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038651727.1 → XP_038507655.1  peripheral plasma membrane protein CASK isoform X14

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:739 → 912
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    2. XM_038651736.1 → XP_038507664.1  peripheral plasma membrane protein CASK isoform X19

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    3. XM_038651733.1 → XP_038507661.1  peripheral plasma membrane protein CASK isoform X18

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:599 → 660
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:721 → 894
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    4. XM_038651732.1 → XP_038507660.1  peripheral plasma membrane protein CASK isoform X17

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    5. XM_038651725.1 → XP_038507653.1  peripheral plasma membrane protein CASK isoform X13

      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:744 → 917
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    6. XM_038651729.1 → XP_038507657.1  peripheral plasma membrane protein CASK isoform X15

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    7. XM_038651728.1 → XP_038507656.1  peripheral plasma membrane protein CASK isoform X1

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    8. XM_038651737.1 → XP_038507665.1  peripheral plasma membrane protein CASK isoform X20

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:575 → 636
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:692 → 865
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    9. XM_038651731.1 → XP_038507659.1  peripheral plasma membrane protein CASK isoform X16

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    10. XM_038651735.1 → XP_038507663.1  peripheral plasma membrane protein CASK isoform X4

      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    11. XM_038651734.1 → XP_038507662.1  peripheral plasma membrane protein CASK isoform X3

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:710 → 883
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    12. XM_038651730.1 → XP_038507658.1  peripheral plasma membrane protein CASK isoform X2

      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:733 → 906
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      36082753..36433406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038587210.1 → XP_038443138.1  peripheral plasma membrane protein CASK isoform X22

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8C0SHD9, A0A8I3PPZ6, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:739 → 912
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    2. XM_038587220.1 → XP_038443148.1  peripheral plasma membrane protein CASK isoform X27

      UniProtKB/TrEMBL
      A0A8C0NDJ2
      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    3. XM_038587216.1 → XP_038443144.1  peripheral plasma membrane protein CASK isoform X26

      UniProtKB/TrEMBL
      A0A8P0NQ62
      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:599 → 660
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:721 → 894
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    4. XM_038587215.1 → XP_038443143.1  peripheral plasma membrane protein CASK isoform X25

      UniProtKB/TrEMBL
      A0A8P0TC19
      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    5. XM_038587209.1 → XP_038443137.1  peripheral plasma membrane protein CASK isoform X21

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:354 → 407
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:622 → 683
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:494 → 574
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:744 → 917
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:412 → 462
      L27; L27 domain

    6. XM_038587212.1 → XP_038443140.1  peripheral plasma membrane protein CASK isoform X23

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 313
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    7. XM_038587211.1 → XP_038443139.1  peripheral plasma membrane protein CASK isoform X1

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:738 → 911
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    8. XM_038587221.1 → XP_038443149.1  peripheral plasma membrane protein CASK isoform X28

      UniProtKB/TrEMBL
      A0A8C0NDJ2
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:575 → 636
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:692 → 865
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    9. XM_038587214.1 → XP_038443142.1  peripheral plasma membrane protein CASK isoform X24

      UniProtKB/TrEMBL
      A0A8C0N6V9, A0A8C0SHD4, A0A8I3PNE8, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:610 → 671
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:732 → 905
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    10. XM_038587219.1 → XP_038443147.1  peripheral plasma membrane protein CASK isoform X4

      UniProtKB/TrEMBL
      A0A8P0NQ62
      Conserved Domains (6) summary
      smart00569
      Location:342 → 395
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:587 → 648
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:482 → 562
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:709 → 882
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:400 → 450
      L27; L27 domain

    11. XM_038587218.1 → XP_038443146.1  peripheral plasma membrane protein CASK isoform X3

      UniProtKB/TrEMBL
      A0A8C0NDJ2
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:710 → 883
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    12. XM_038587213.1 → XP_038443141.1  peripheral plasma membrane protein CASK isoform X2

      UniProtKB/TrEMBL
      A0A8C0SHD4, A0A8I3PQD3
      Conserved Domains (6) summary
      smart00569
      Location:348 → 401
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:616 → 677
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:488 → 568
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14094
      Location:8 → 307
      STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
      pfam00625
      Location:733 → 906
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:406 → 456
      L27; L27 domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23287445..23579098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038464780.1 → XP_038320708.1  peripheral plasma membrane protein CASK isoform X29

      UniProtKB/TrEMBL
      A0A8P0NG04
      Conserved Domains (6) summary
      smart00569
      Location:325 → 378
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12081
      Location:593 → 654
      SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
      cd00992
      Location:465 → 545
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:715 → 888
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:383 → 433
      L27; L27 domain
      cl21453
      Location:8 → 284
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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