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    CLTC clathrin heavy chain [ Canis lupus familiaris (dog) ]

    Gene ID: 480578, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CLTCprovided by VGNC
    Official Full Name
    clathrin heavy chainprovided by VGNC
    Primary source
    VGNC:VGNC:39367
    See related
    Ensembl:ENSCAFG00845025273
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CLTC in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (34925162..34993363)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (33348834..33415377)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (34082574..34149196)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (33708907..33777008)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (33995028..34063165)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097411 Neighboring gene uncharacterized LOC111097412 Neighboring gene DEAH-box helicase 40 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene vacuole membrane protein 1 Neighboring gene microRNA mir-21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clathrin is a key regulator of basolateral polarity. Deborde S, et al. Nature, 2008 Apr 10. PMID 18401403, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables clathrin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of clathrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in clathrin-coated endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    clathrin heavy chain 1; LOW QUALITY PROTEIN: clathrin heavy chain 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      34925162..34993363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038677160.1 → XP_038533088.1  clathrin heavy chain 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LRS6, A0A8C0MFZ6, A0A8I3PQE6
      Related
      ENSCAFP00845035373.1, ENSCAFT00845045118.1
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    2. XM_038677161.1 → XP_038533089.1  clathrin heavy chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0ME72
      Related
      ENSCAFP00845035009.1, ENSCAFT00845044680.1
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      33708907..33777008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038486135.1 → XP_038342063.1  clathrin heavy chain 1 isoform X1

      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    2. XM_038486136.1 → XP_038342064.1  clathrin heavy chain 1 isoform X2

      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      33995028..34063165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038611920.1 → XP_038467848.1  clathrin heavy chain 1 isoform X1

      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    2. XM_038611921.1 → XP_038467849.1  clathrin heavy chain 1 isoform X2

      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      34082574..34149196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038547956.1 → XP_038403884.1  LOW QUALITY PROTEIN: clathrin heavy chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0ME72
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      33348834..33415377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005624748.4 → XP_005624805.1  clathrin heavy chain 1 isoform X1

      See identical proteins and their annotated locations for XP_005624805.1

      UniProtKB/TrEMBL
      A0A8C0LRS6, A0A8C0MFZ6, A0A8I3PQE6
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link

    2. XM_537700.7 → XP_537700.2  clathrin heavy chain 1 isoform X2

      See identical proteins and their annotated locations for XP_537700.2

      UniProtKB/TrEMBL
      A0A8C0ME72
      Conserved Domains (6) summary
      smart00299
      Location:1274 → 1416
      CLH; Clathrin heavy chain repeat homology
      sd00006
      Location:1105 → 1131
      TPR; TPR repeat [structural motif]
      pfam00637
      Location:979 → 1119
      Clathrin; Region in Clathrin and VPS
      pfam01394
      Location:198 → 234
      Clathrin_propel; Clathrin propeller repeat
      pfam09268
      Location:331 → 354
      Clathrin-link; Clathrin, heavy-chain linker
      pfam13838
      Location:356 → 421
      Clathrin_H_link; Clathrin-H-link
    Nucleotide Protein
    Heading Accession and Version

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