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    TOP2A DNA topoisomerase II alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 480525, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TOP2Aprovided by VGNC
    Official Full Name
    DNA topoisomerase II alphaprovided by VGNC
    Primary source
    VGNC:VGNC:49098
    See related
    Ensembl:ENSCAFG00845008263
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TOP2A in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (23000244..23030254)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (21679941..21709943)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (22157897..22187909)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (21774298..21804337)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (22033150..22063078)

    Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene tensin 4 Neighboring gene microRNA mir-8888 Neighboring gene uncharacterized LOC106559289 Neighboring gene insulin like growth factor binding protein 4 Neighboring gene uncharacterized LOC111097355 Neighboring gene TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa pseudogene Neighboring gene uncharacterized LOC102153525 Neighboring gene gap junction protein delta 3 Neighboring gene retinoic acid receptor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines. Packeiser EM, et al. Int J Mol Sci, 2023 May 2. PMID 37175843, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines.
      Title: MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in apoptotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 2-alpha; LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha
    Names
    topoisomerase (DNA) II alpha 170kDa
    XP_038341539.1
    XP_038341540.1
    XP_038403306.1
    XP_038459123.1
    XP_038467289.1
    XP_038467290.1
    XP_038532481.1
    XP_038532482.1
    XP_537646.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051813.1 Reference ROS_Cfam_1.0

      Range
      23000244..23030254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038676554.1 → XP_038532482.1  DNA topoisomerase 2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0NHM0, A0A8C0SLK5, A0A8I3MXG1
      Related
      ENSCAFP00845011307.1, ENSCAFT00845014593.1
      Conserved Domains (2) summary
      PTZ00108
      Location:25 → 1402
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1436 → 1522
      DTHCT; DTHCT (NUC029) region

    2. XM_038676553.1 → XP_038532481.1  DNA topoisomerase 2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NHM0, A0A8I3N3P1, A0A8P0NTK0
      Related
      ENSCAFP00845011528.1, ENSCAFT00845014873.1
      Conserved Domains (2) summary
      PTZ00108
      Location:34 → 1411
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1445 → 1531
      DTHCT; DTHCT (NUC029) region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049269.1 Alternate UMICH_Zoey_3.1

      Range
      21774298..21804337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038485612.1 → XP_038341540.1  DNA topoisomerase 2-alpha isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:25 → 1402
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1436 → 1522
      DTHCT; DTHCT (NUC029) region

    2. XM_038485611.1 → XP_038341539.1  DNA topoisomerase 2-alpha isoform X1

      Conserved Domains (2) summary
      PTZ00108
      Location:34 → 1411
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1445 → 1531
      DTHCT; DTHCT (NUC029) region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

      Range
      22033150..22063078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038611362.1 → XP_038467290.1  DNA topoisomerase 2-alpha isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:25 → 1402
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1436 → 1522
      DTHCT; DTHCT (NUC029) region

    2. XM_038611361.1 → XP_038467289.1  DNA topoisomerase 2-alpha isoform X1

      Conserved Domains (2) summary
      PTZ00108
      Location:34 → 1411
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1445 → 1531
      DTHCT; DTHCT (NUC029) region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

      Range
      22157897..22187909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038547378.1 → XP_038403306.1  LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0NHM0, A0A8C0SLK5, A0A8I3MXG1
      Conserved Domains (2) summary
      PTZ00108
      Location:25 → 1402
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1436 → 1522
      DTHCT; DTHCT (NUC029) region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21679941..21709943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_537646.6 → XP_537646.3  DNA topoisomerase 2-alpha isoform X2

      UniProtKB/TrEMBL
      A0A8C0NHM0, A0A8C0SLK5, A0A8I3MXG1
      Conserved Domains (2) summary
      PTZ00108
      Location:25 → 1402
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1436 → 1522
      DTHCT; DTHCT (NUC029) region

    2. XM_038603195.1 → XP_038459123.1  DNA topoisomerase 2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0NHM0, A0A8I3N3P1, A0A8P0NTK0
      Conserved Domains (2) summary
      PTZ00108
      Location:34 → 1411
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:1445 → 1531
      DTHCT; DTHCT (NUC029) region
    Nucleotide Protein
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