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    TTC8 tetratricopeptide repeat domain 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 480413, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TTC8provided by VGNC
    Official Full Name
    tetratricopeptide repeat domain 8provided by VGNC
    Primary source
    VGNC:VGNC:47963
    See related
    Ensembl:ENSCAFG00845012241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TTC8 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (60332658..60386187)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (59641066..59693906)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (60391356..60444177)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (60013742..60066541)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (60063485..60116262)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene 40S ribosomal protein S15a-like Neighboring gene EMAP like 5 Neighboring gene forkhead box N3 Neighboring gene uncharacterized LOC111097135 Neighboring gene uncharacterized LOC102156073

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs. Mäkeläinen S, et al. Genes (Basel), 2020 Sep 18. PMID 32962042, Free PMC Article
    2. FAM161A and TTC8 are Differentially Expressed in Non-Allelelic Early Onset Retinal Degeneration. Downs LM, et al. Adv Exp Med Biol, 2016. PMID 26427412, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs.
      Title: Deletion in the Bardet-Biedl Syndrome Gene TTC8 Results in a Syndromic Retinal Degeneration in Dogs.
    2. Data indicate taht the expression of FAM161A and TTC8 was highest at 3 and 5 weeks of age, followed by decreased expression to the levels in the 16 week retina.
      Title: FAM161A and TTC8 are Differentially Expressed in Non-Allelelic Early Onset Retinal Degeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BBSome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284469.1 → NP_001271398.1  tetratricopeptide repeat protein 8

      See identical proteins and their annotated locations for NP_001271398.1

      Status: PROVISIONAL

      Source sequence(s)
      JQ941743
      UniProtKB/TrEMBL
      A0A8C0KVK4, A0A8C0PUU0, A0A8P0SWK4, R4ITK9
      Conserved Domains (2) summary
      COG0457
      Location:231 → 488
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:220 → 243
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      60332658..60386187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038672886.1 → XP_038528814.1  tetratricopeptide repeat protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I3NKT7, A0A8I3NM60
      Related
      ENSCAFP00845017191.1, ENSCAFT00845021855.1
      Conserved Domains (3) summary
      COG0457
      Location:241 → 498
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:230 → 253
      TPR; TPR repeat [structural motif]
      cd21341
      Location:30 → 179
      TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

    2. XM_038672889.1 → XP_038528817.1  tetratricopeptide repeat protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I3NLA0, A0A8I3NPG7
      Related
      ENSCAFP00845017438.1, ENSCAFT00845022177.1
      Conserved Domains (3) summary
      COG0457
      Location:181 → 438
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:170 → 193
      TPR; TPR repeat [structural motif]
      cd21341
      Location:1 → 119
      TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

    3. XM_038672888.1 → XP_038528816.1  tetratricopeptide repeat protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NLA0
      Related
      ENSCAFP00845017373.1, ENSCAFT00845022096.1
      Conserved Domains (3) summary
      COG0457
      Location:194 → 451
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:183 → 206
      TPR; TPR repeat [structural motif]
      cd21341
      Location:2 → 132
      TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      60013742..60066541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      60063485..60116262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      60391356..60444177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      59641066..59693906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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