U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 480352, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MTHFD1provided by VGNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:43472
    See related
    Ensembl:ENSCAFG00845002014
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MTHFD1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (39053525..39110717)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (38523089..38581005)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (39107099..39164254)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (38674867..38732782)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (38746016..38804174)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097074 Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene nucleoside diphosphate kinase A-like Neighboring gene U4 spliceosomal RNA Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 25

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methenyltetrahydrofolate cyclohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    C-1-tetrahydrofolate synthase, cytoplasmic
    XP_038339387.1
    XP_038339388.1
    XP_038400847.1
    XP_038400848.1
    XP_038445110.1
    XP_038464963.1
    XP_038464964.1
    XP_038529768.1
    XP_038529769.1
    XP_537476.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      39053525..39110717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038673840.1 → XP_038529768.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
      Related
      ENSCAFP00845002795.1, ENSCAFT00845003522.1
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_038673841.1 → XP_038529769.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8C0QKW9
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 910
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      38674867..38732782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038483459.1 → XP_038339387.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_038483460.1 → XP_038339388.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      Conserved Domains (2) summary
      PLN02759
      Location:310 → 910
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      38746016..38804174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038609035.1 → XP_038464963.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_038609036.1 → XP_038464964.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      Conserved Domains (2) summary
      PLN02759
      Location:310 → 910
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      39107099..39164254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038544919.1 → XP_038400847.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_038544920.1 → XP_038400848.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8C0QKW9
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 910
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      38523089..38581005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_537476.7 → XP_537476.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8C0P838, A0A8C0QQP0, A0A8I3MJJ7
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 935
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_038589182.1 → XP_038445110.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8C0QKW9
      Conserved Domains (2) summary
      PLN02759
      Location:310 → 910
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:6 → 294
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.