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    PDE4B phosphodiesterase 4B [ Canis lupus familiaris (dog) ]

    Gene ID: 479540, updated on 17-Aug-2024

    Summary

    Official Symbol
    PDE4Bprovided by VGNC
    Official Full Name
    phosphodiesterase 4Bprovided by VGNC
    Primary source
    VGNC:VGNC:44354
    See related
    Ensembl:ENSCAFG00845028786
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PDE4B in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (44251621..44793357, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (44186161..44663652, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (44405153..44947628, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (44216433..44758769, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (44161847..44703948, complement)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095919 Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene uncharacterized LOC111095920 Neighboring gene uncharacterized LOC102156117 Neighboring gene uncharacterized LOC111095923 Neighboring gene uncharacterized LOC111095922 Neighboring gene uncharacterized LOC111095924 Neighboring gene uncharacterized LOC102155947 Neighboring gene ADP/ATP translocase 2-like Neighboring gene uncharacterized LOC111095921 Neighboring gene ATP synthase subunit d, mitochondrial-like Neighboring gene uncharacterized LOC102156371 Neighboring gene leptin receptor Neighboring gene uncharacterized LOC111096111

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Names
    phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
    XP_003434692.1
    XP_013969180.1
    XP_013969181.1
    XP_022274421.1
    XP_038331964.1
    XP_038331965.1
    XP_038331966.1
    XP_038331967.1
    XP_038331968.1
    XP_038331969.1
    XP_038331970.1
    XP_038331971.1
    XP_038374914.1
    XP_038374937.1
    XP_038393150.1
    XP_038393151.1
    XP_038393152.1
    XP_038393153.1
    XP_038393154.1
    XP_038393155.1
    XP_038393156.1
    XP_038393157.1
    XP_038457278.1
    XP_038457279.1
    XP_038457280.1
    XP_038457281.1
    XP_038457282.1
    XP_038457283.1
    XP_038457284.1
    XP_038457285.1
    XP_038521844.1
    XP_038521845.1
    XP_038521846.1
    XP_038521847.1
    XP_038521848.1
    XP_038521849.1
    XP_038521850.1
    XP_038521851.1
    XP_536678.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      44251621..44793357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038665916.1XP_038521844.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Related
      ENSCAFP00845040013.1, ENSCAFT00845051038.1
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    2. XM_038665917.1XP_038521845.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_038665920.1XP_038521848.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0L722
      Conserved Domains (2) summary
      pfam00233
      Location:314555
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74190
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    4. XM_038665918.1XP_038521846.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
      Related
      ENSCAFP00845040044.1, ENSCAFT00845051078.1
      Conserved Domains (2) summary
      pfam00233
      Location:391632
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151267
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    5. XM_038665919.1XP_038521847.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      UniProtKB/TrEMBL
      A0A8C0L722
      Conserved Domains (2) summary
      pfam00233
      Location:329570
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89205
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. XM_038665922.1XP_038521850.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. XM_038665921.1XP_038521849.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
      Related
      ENSCAFP00845040064.1, ENSCAFT00845051098.1
      Conserved Domains (2) summary
      pfam00233
      Location:206447
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    8. XM_038665923.1XP_038521851.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

      UniProtKB/TrEMBL
      A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
      Related
      ENSCAFP00845040242.1, ENSCAFT00845051302.1
      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      44216433..44758769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038476036.1XP_038331964.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    2. XM_038476037.1XP_038331965.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_038476040.1XP_038331968.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

      Conserved Domains (2) summary
      pfam00233
      Location:314555
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74190
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    4. XM_038476038.1XP_038331966.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      Conserved Domains (2) summary
      pfam00233
      Location:391632
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151267
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    5. XM_038476039.1XP_038331967.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      Conserved Domains (2) summary
      pfam00233
      Location:329570
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89205
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. XM_038476042.1XP_038331970.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. XM_038476041.1XP_038331969.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

      Conserved Domains (2) summary
      pfam00233
      Location:206447
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    8. XM_038476043.1XP_038331971.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      44161847..44703948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038601350.1XP_038457278.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    2. XM_038601351.1XP_038457279.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_038601354.1XP_038457282.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

      Conserved Domains (2) summary
      pfam00233
      Location:314555
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74190
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    4. XM_038601352.1XP_038457280.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      Conserved Domains (2) summary
      pfam00233
      Location:391632
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151267
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    5. XM_038601353.1XP_038457281.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      Conserved Domains (2) summary
      pfam00233
      Location:329570
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89205
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. XM_038601356.1XP_038457284.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. XM_038601355.1XP_038457283.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

      Conserved Domains (2) summary
      pfam00233
      Location:206447
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    8. XM_038601357.1XP_038457285.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      44405153..44947628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038537222.1XP_038393150.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    2. XM_038537223.1XP_038393151.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_038537226.1XP_038393154.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0L722
      Conserved Domains (2) summary
      pfam00233
      Location:314555
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74190
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    4. XM_038537224.1XP_038393152.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
      Conserved Domains (2) summary
      pfam00233
      Location:391632
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151267
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    5. XM_038537225.1XP_038393153.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      UniProtKB/TrEMBL
      A0A8C0L722
      Conserved Domains (2) summary
      pfam00233
      Location:329570
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89205
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. XM_038537228.1XP_038393156.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. XM_038537227.1XP_038393155.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
      Conserved Domains (2) summary
      pfam00233
      Location:206447
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    8. XM_038537229.1XP_038393157.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

      UniProtKB/TrEMBL
      A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      44186161..44663652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003434644.5XP_003434692.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      See identical proteins and their annotated locations for XP_003434692.1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    2. XM_038518986.1XP_038374914.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
      Conserved Domains (2) summary
      pfam00233
      Location:406647
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    3. XM_022418713.2XP_022274421.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0L722
      Conserved Domains (2) summary
      pfam00233
      Location:314555
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:74190
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    4. XM_536678.7XP_536678.3  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
      Conserved Domains (2) summary
      pfam00233
      Location:391632
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151267
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    5. XM_038519009.1XP_038374937.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

      Conserved Domains (2) summary
      pfam00233
      Location:186427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:162
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. XM_014113705.3XP_013969180.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

      UniProtKB/TrEMBL
      A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
      Conserved Domains (2) summary
      pfam00233
      Location:206447
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1282
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    7. XM_014113706.3XP_013969181.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

      UniProtKB/TrEMBL
      A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
      Conserved Domains (2) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1648
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)