RETREG1 reticulophagy regulator 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: RETREG1provided by VGNC
Official Full Name: reticulophagy regulator 1provided by VGNC
Primary source: VGNC:VGNC:45483
See related: Ensembl:ENSCAFG00845003719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: FAM134B
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (87442470..87564197)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (86323200..86438561)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (88059445..88174500)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (86965905..87080546)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (87202448..87317283)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using a genome-wide association study approach with three cases and 170 breed matched controls, a suggestive locus for sensory neuropathy was identified that was followed up using a genome sequencing approach. An inversion disrupting the candidate gene FAM134B was identified.
Title: An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in reticulophagy	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: reticulophagy regulator 1

Names: family with sequence similarity 134 member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001314111.1 → NP_001301040.1 reticulophagy regulator 1

Status: PROVISIONAL

Source sequence(s)

KR119069

UniProtKB/TrEMBL

A0A0K1MBN7, A0A8C0R4J3, A0A8I3MIY6

Related

ENSCAFP00845005290.1, ENSCAFT00845006651.1

Conserved Domains (1) summary

pfam02453
Location:73 → 221

Reticulon; Reticulon

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051808.1 Reference ROS_Cfam_1.0

Range

87442470..87564197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038662293.1 → XP_038518221.1 reticulophagy regulator 1 isoform X1

Conserved Domains (1) summary

cl41772
Location:12 → 118

Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
XM_038662294.1 → XP_038518222.1 reticulophagy regulator 1 isoform X2

Conserved Domains (1) summary

cl41772
Location:7 → 112

Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins