FCER1A Fc epsilon receptor Ia [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: FCER1Aprovided by VGNC
Official Full Name: Fc epsilon receptor Iaprovided by VGNC
Primary source: VGNC:VGNC:40801
See related: Ensembl:ENSCAFG00845015284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 38

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	38	NC_051842.1 (22806067..22811504, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	38	NC_006620.4 (22695550..22700839, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	38	NC_049259.1 (23556483..23561775, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	38	NC_049298.1 (22570794..22576081, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	38	NC_049779.1 (23105066..23110355, complement)

Chromosome 38 - NC_051842.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Canine C epsilon3 is the only domain essential for binding to canine or human Fc epsilon RI alpha, species specific residues in canine Cepsilon2 and C epsilon4 inhibit dissociation of the ligand from the receptor.[Fc epsilon RI alpha]
Title: Generation of canine-human Fc IgE chimeric antibodies for the determination of the canine IgE domain of interaction with Fc epsilon RI alpha.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: high affinity immunoglobulin epsilon receptor subunit alpha

Names: Fc fragment of IgE receptor Ia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110766.3 → NP_001104236.2 high affinity immunoglobulin epsilon receptor subunit alpha precursor

Status: VALIDATED

Source sequence(s)

JAAUVH010000370

UniProtKB/TrEMBL

A0A8C0L879

Related

ENSCAFP00845021454.1, ENSCAFT00845027266.1

Conserved Domains (2) summary

smart00410
Location:121 → 194

IG_like; Immunoglobulin like

cl11960
Location:112 → 194

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051842.1 Reference ROS_Cfam_1.0

Range

22806067..22811504 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038448132.1 → XP_038304060.1 high affinity immunoglobulin epsilon receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A0A8I3NZS7, A0A8P0SGG2

Conserved Domains (3) summary

cd00096
Location:57 → 60

Ig; Ig strand A [structural motif]

cd05753
Location:138 → 220

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cl11960
Location:56 → 134

Ig; Immunoglobulin domain