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    IDH1 isocitrate dehydrogenase (NADP(+)) 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478889, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IDH1provided by VGNC
    Official Full Name
    isocitrate dehydrogenase (NADP(+)) 1provided by VGNC
    Primary source
    VGNC:VGNC:110512
    See related
    Ensembl:ENSCAFG00845023478
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See IDH1 in Genome Data Viewer
    Location:
    chromosome: 37
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (16447690..16466938, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (17394694..17413933, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (16374393..16393573, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (16391770..16406979, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (16365144..16384346, complement)

    Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867950 Neighboring gene chromosome 37 C2orf80 homolog Neighboring gene crystallin gamma A Neighboring gene uncharacterized LOC106558325 Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene parathyroid hormone 2 receptor Neighboring gene elongation factor 1-alpha 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes. Kawakami S, et al. Vet Res Commun, 2018 Mar. PMID 29285579
    2. Housekeeping genes for phylogenetic analysis of eutherian relationships. Kullberg M, et al. Mol Biol Evol, 2006 Aug. PMID 16751257
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. canine IDH1 Arg132 mutation has the potential to induce carcinogenesis in canine somatic cells.
      Title: R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isocitrate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic; LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    isocitrate dehydrogenase (NADP(+)) 1, cytosolic
    XP_013966568.1
    XP_038303722.1
    XP_038303723.1
    XP_038377778.1
    XP_038441511.1
    XP_038441512.1
    XP_038505892.1
    XP_038505893.1
    XP_536047.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051841.1 Reference ROS_Cfam_1.0

      Range
      16447690..16466938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038447795.1 → XP_038303723.1  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Related
      ENSCAFP00845032495.1, ENSCAFT00845041440.1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. XM_038447794.1 → XP_038303722.1  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049297.1 Alternate UMICH_Zoey_3.1

      Range
      16391770..16406979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038521850.1 → XP_038377778.1  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NADP] cytoplasmic

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

      Range
      16365144..16384346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038649965.1 → XP_038505893.1  isocitrate dehydrogenase [NADP] cytoplasmic

      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. XM_038649964.1 → XP_038505892.1  isocitrate dehydrogenase [NADP] cytoplasmic

      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

      Range
      16374393..16393573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038585584.1 → XP_038441512.1  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. XM_038585583.1 → XP_038441511.1  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      17394694..17413933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_536047.6 → XP_536047.2  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. XM_014111093.3 → XP_013966568.1  isocitrate dehydrogenase [NADP] cytoplasmic

      UniProtKB/TrEMBL
      A0A8C0MYC5, A0A8C0S1K7, F1PZA1
      Conserved Domains (1) summary
      PTZ00435
      Location:1 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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