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    MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase [ Canis lupus familiaris (dog) ]

    Gene ID: 478623, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MTRRprovided by VGNC
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferase reductaseprovided by VGNC
    Primary source
    VGNC:VGNC:49927
    See related
    Ensembl:ENSCAFG00845022722
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See MTRR in Genome Data Viewer
    Location:
    chromosome: 34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (5974025..6005680, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (10576595..10608261, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (6217429..6249109, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (6023818..6055451, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (6004603..6036228, complement)

    Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093954 Neighboring gene synaptosomal-associated protein 29-like Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene uncharacterized LOC119867423 Neighboring gene FAST kinase domains 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables [methionine synthase] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homocysteine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine synthase reductase
    XP_005639736.1
    XP_038301442.1
    XP_038375622.1
    XP_038439262.1
    XP_038503679.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051838.1 Reference ROS_Cfam_1.0

      Range
      5974025..6005680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038445514.1 → XP_038301442.1  methionine synthase reductase

      UniProtKB/TrEMBL
      A0A8C0LEM3, A0A8C0TMK9, A0A8I3PQ14
      Related
      ENSCAFP00845031407.1, ENSCAFT00845040107.1
      Conserved Domains (2) summary
      cd06203
      Location:276 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1

    RNA

    1. XR_005306709.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049294.1 Alternate UMICH_Zoey_3.1

      Range
      6023818..6055451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038519694.1 → XP_038375622.1  methionine synthase reductase

      Conserved Domains (2) summary
      cd06203
      Location:276 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1

    RNA

    1. XR_005349695.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

      Range
      6004603..6036228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038647751.1 → XP_038503679.1  methionine synthase reductase

    RNA

    1. XR_005417331.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

      Range
      6217429..6249109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038583334.1 → XP_038439262.1  methionine synthase reductase

      UniProtKB/TrEMBL
      A0A8C0LEM3, A0A8C0TMK9, A0A8I3PQ14
      Conserved Domains (2) summary
      cd06203
      Location:276 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1

    RNA

    1. XR_005383675.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      10576595..10608261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005639679.4 → XP_005639736.1  methionine synthase reductase

      See identical proteins and their annotated locations for XP_005639736.1

      UniProtKB/TrEMBL
      A0A8C0LEM3, A0A8C0TMK9, A0A8I3PQ14
      Conserved Domains (2) summary
      cd06203
      Location:276 → 696
      methionine_synthase_red; Human methionine synthase reductase (MSR) restores methionine sythase which is responsible for the regeneration of methionine from homocysteine, as well as the coversion of methyltetrahydrofolate to tetrahydrofolate. In MSR, electrons are transferred ...
      pfam00258
      Location:6 → 142
      Flavodoxin_1

    RNA

    1. XR_002622781.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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