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    MAP3K1 mitogen-activated protein kinase kinase kinase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478061, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MAP3K1provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:42966
    See related
    Ensembl:ENSCAFG00845028679
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See MAP3K1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (44400091..44478773)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (40979535..41058128)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (43100342..43179022)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (41477057..41555639)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (42280433..42359075)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092268 Neighboring gene dual specificity protein phosphatase 5-like Neighboring gene uncharacterized LOC106557898 Neighboring gene small nucleolar RNA U3 Neighboring gene SET domain containing 9 Neighboring gene MIER family member 3 Neighboring gene uncharacterized LOC119870239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 1
    XP_038325748.1
    XP_038386556.1
    XP_038450802.1
    XP_038514848.1
    XP_535240.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      44400091..44478773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038658920.1 → XP_038514848.1  mitogen-activated protein kinase kinase kinase 1

      UniProtKB/TrEMBL
      A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
      Related
      ENSCAFP00845039758.1, ENSCAFT00845050716.1
      Conserved Domains (2) summary
      cd06630
      Location:1237 → 1504
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:440 → 495
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      41477057..41555639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038469820.1 → XP_038325748.1  mitogen-activated protein kinase kinase kinase 1

      Conserved Domains (2) summary
      cd06630
      Location:1237 → 1504
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:440 → 495
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      42280433..42359075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038594874.1 → XP_038450802.1  mitogen-activated protein kinase kinase kinase 1

      Conserved Domains (2) summary
      cd06630
      Location:1237 → 1504
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:440 → 495
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      43100342..43179022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038530628.1 → XP_038386556.1  mitogen-activated protein kinase kinase kinase 1

      UniProtKB/TrEMBL
      A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
      Conserved Domains (2) summary
      cd06630
      Location:1237 → 1504
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:440 → 495
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      40979535..41058128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_535240.7 → XP_535240.4  mitogen-activated protein kinase kinase kinase 1

      UniProtKB/TrEMBL
      A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
      Conserved Domains (2) summary
      cd06630
      Location:1237 → 1504
      STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
      cd16494
      Location:440 → 495
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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