HARS1 histidyl-tRNA synthetase 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HARS1provided by VGNC
Official Full Name: histidyl-tRNA synthetase 1provided by VGNC
Primary source: VGNC:VGNC:41597
See related: Ensembl:ENSCAFG00845002179
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: HARS
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (36283853..36299236, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (32867230..32882606, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (34956682..34972058, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (33336188..33351339, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (34203967..34219341, complement)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histidine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in histidyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitochondrial translation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histidine--tRNA ligase, cytoplasmic

XP_005617343.1

EC 6.1.1.21

XP_038325511.1

EC 6.1.1.21

XP_038325512.1

EC 6.1.1.21

XP_038386276.1

EC 6.1.1.21

XP_038386277.1

EC 6.1.1.21

XP_038450527.1

EC 6.1.1.21

XP_038450528.1

EC 6.1.1.21

XP_038514568.1

EC 6.1.1.21

XP_038514569.1

EC 6.1.1.21

XP_535213.2

EC 6.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

36283853..36299236 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038658640.1 → XP_038514568.1 histidine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8I3MFI9, A0A8P0TUT0

Conserved Domains (2) summary

PLN02972
Location:57 → 486

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
XM_038658641.1 → XP_038514569.1 histidine--tRNA ligase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A8C0JHU3, A0A8C0RDL4, A0A8I3MFI9, A0A8I3MNZ5, A0A8P0TUT0

Related

ENSCAFP00845003173.1, ENSCAFT00845003972.1

Conserved Domains (2) summary

PLN02972
Location:57 → 505

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049262.1 Alternate UMICH_Zoey_3.1

Range

33336188..33351339 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038469583.1 → XP_038325511.1 histidine--tRNA ligase, cytoplasmic isoform X1

Conserved Domains (2) summary

PLN02972
Location:57 → 486

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
XM_038469584.1 → XP_038325512.1 histidine--tRNA ligase, cytoplasmic isoform X2

Conserved Domains (2) summary

PLN02972
Location:57 → 505

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049743.1 Alternate UNSW_CanFamBas_1.0

Range

34203967..34219341 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038594600.1 → XP_038450528.1 histidine--tRNA ligase, cytoplasmic isoform X2

Conserved Domains (2) summary

PLN02972
Location:57 → 505

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
XM_038594599.1 → XP_038450527.1 histidine--tRNA ligase, cytoplasmic isoform X1

Conserved Domains (2) summary

PLN02972
Location:57 → 486

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049223.1 Alternate UU_Cfam_GSD_1.0

Range

34956682..34972058 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038530348.1 → XP_038386276.1 histidine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8I3MFI9, A0A8P0TUT0

Conserved Domains (2) summary

PLN02972
Location:57 → 486

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
XM_038530349.1 → XP_038386277.1 histidine--tRNA ligase, cytoplasmic isoform X2

UniProtKB/TrEMBL

A0A8C0JHU3, A0A8C0RDL4, A0A8I3MFI9, A0A8I3MNZ5, A0A8P0TUT0

Conserved Domains (2) summary

PLN02972
Location:57 → 505

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

32867230..32882606 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005617286.4 → XP_005617343.1 histidine--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A8I3MFI9, A0A8P0TUT0

Conserved Domains (2) summary

PLN02972
Location:57 → 486

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...
XM_535213.6 → XP_535213.2 histidine--tRNA ligase, cytoplasmic isoform X2

See identical proteins and their annotated locations for XP_535213.2

UniProtKB/TrEMBL

A0A8C0JHU3, A0A8C0RDL4, A0A8I3MFI9, A0A8I3MNZ5, A0A8P0TUT0

Conserved Domains (2) summary

PLN02972
Location:57 → 505

PLN02972; Histidyl-tRNA synthetase

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...