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    HTRA1 HtrA serine peptidase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 477852, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HTRA1provided by VGNC
    Official Full Name
    HtrA serine peptidase 1provided by VGNC
    Primary source
    VGNC:VGNC:41835
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PRSS11
    Orthologs
    human mouse all
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    Genomic context

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    See HTRA1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (32639924..32693737)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (32180049..32232586)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (32398590..32451692)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (32172101..32225511)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (32194497..32247262)

    Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866530 Neighboring gene pleckstrin homology domain containing A1 Neighboring gene deleted in malignant brain tumors 1 Neighboring gene uncharacterized LOC119866609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 in canine mammary gland cancer. Sobral RA, et al. Acta Vet Scand, 2008 Jul 4. PMID 18601734, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three-dimensional distribution of samples according to the expression of the trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 could not predict doxorubicin in vitro responsiveness in canine mammary gland tumor slices.
      Title: Tumor slices as a model to evaluate doxorubicin in vitro treatment and expression of trios of genes PRSS11, MTSS1, CLPTM1 and PRSS11, MTSS1, SMYD2 in canine mammary gland cancer.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease HTRA1; LOW QUALITY PROTEIN: serine protease HTRA1
    XP_038295584.1
    XP_038316426.1
    XP_038371550.1
    XP_038433910.1
    XP_038499153.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051832.1 Reference ROS_Cfam_1.0

      Range
      32639924..32693737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038439656.1 → XP_038295584.1  serine protease HTRA1 isoform X1

      Conserved Domains (3) summary
      smart00121
      Location:164 → 240
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:246 → 284
      KAZAL; Kazal type serine protease inhibitors
      TIGR02037
      Location:301 → 603
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049288.1 Alternate UMICH_Zoey_3.1

      Range
      32172101..32225511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038515622.1 → XP_038371550.1  serine protease HTRA1 isoform X2

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

      Range
      32194497..32247262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038643225.1 → XP_038499153.1  serine protease HTRA1 isoform X3

      Conserved Domains (3) summary
      smart00121
      Location:24 → 100
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:106 → 144
      KAZAL; Kazal type serine protease inhibitors
      TIGR02037
      Location:161 → 463
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

      Range
      32398590..32451692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038577982.1 → XP_038433910.1  LOW QUALITY PROTEIN: serine protease HTRA1 isoform X4

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      32180049..32232586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038460498.1 → XP_038316426.1  serine protease HTRA1 isoform X5

      Conserved Domains (3) summary
      smart00121
      Location:24 → 100
      IB; Insulin growth factor-binding protein homologues
      smart00280
      Location:106 → 144
      KAZAL; Kazal type serine protease inhibitors
      TIGR02037
      Location:161 → 463
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials