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    PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Canis lupus familiaris (dog) ]

    Gene ID: 477085, updated on 17-Aug-2024

    Summary

    Official Symbol
    PIK3CBprovided by VGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:44556
    See related
    Ensembl:ENSCAFG00845025921
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
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    Genomic context

    See PIK3CB in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (35375472..35581398, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (34826488..35032061, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (35371974..35577846, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (35056048..35262274, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (35121991..35327601, complement)

    Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene acidic leucine-rich nuclear phosphoprotein 32 family member A-like Neighboring gene uncharacterized LOC111091955 Neighboring gene 60S ribosomal protein L17-like Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene forkhead box L2

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
    Names
    phosphoinositide-3-kinase, catalytic, beta polypeptide
    XP_038288402.1
    XP_038288403.1
    XP_038288404.1
    XP_038313250.1
    XP_038313251.1
    XP_038313252.1
    XP_038363707.1
    XP_038363708.1
    XP_038363709.1
    XP_038426949.1
    XP_038426950.1
    XP_038491140.1
    XP_038491142.1
    XP_038491143.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051827.1 Reference ROS_Cfam_1.0

      Range
      35375472..35581398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038432476.1XP_038288404.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_038432474.1XP_038288402.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Related
      ENSCAFP00845035926.1, ENSCAFT00845045772.1
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_038432475.1XP_038288403.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049283.1 Alternate UMICH_Zoey_3.1

      Range
      35056048..35262274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038507781.1XP_038363709.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_038507779.1XP_038363707.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_038507780.1XP_038363708.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

      Range
      35121991..35327601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038635215.1XP_038491143.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_038635212.1XP_038491140.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_038635214.1XP_038491142.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

      Range
      35371974..35577846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038571022.1XP_038426950.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_038571021.1XP_038426949.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      34826488..35032061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038457324.1XP_038313252.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    2. XM_038457322.1XP_038313250.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
    3. XM_038457323.1XP_038313251.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

      UniProtKB/TrEMBL
      A0A8C0K4U5, A0A8C0N9K7, A0A8C0TRF4, A0A8I3PWT3, A0A8I3PX85
      Conserved Domains (5) summary
      cd08693
      Location:324501
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:41118
      PI3K_p85B; PI3-kinase family, p85-binding domain
      smart00144
      Location:180288
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:532702
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:7061067
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta