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    FGA fibrinogen alpha chain [ Canis lupus familiaris (dog) ]

    Gene ID: 475473, updated on 17-Aug-2024

    Summary

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    Official Symbol
    FGAprovided by VGNC
    Official Full Name
    fibrinogen alpha chainprovided by VGNC
    Primary source
    VGNC:VGNC:54205
    See related
    Ensembl:ENSCAFG00845009752
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See FGA in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (52924743..52933990, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (52584628..52591483, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (52601176..52608068, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (52179682..52188900, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (52283995..52293478, complement)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene pleiotropic regulator 1 Neighboring gene fibrinogen beta chain Neighboring gene fibrinogen gamma chain Neighboring gene ribosomal L1 domain-containing protein 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds. Mischke R, et al. Genes (Basel), 2021 Jul 13. PMID 34356081, Free PMC Article
    2. Diversity of primary structures of the carboxy-terminal regions of mammalian fibrinogen A alpha-chains. Characterization of the partial nucleotide and deduced amino acid sequences in five mammalian species; rhesus monkey, pig, dog, mouse and Syrian hamster. Murakawa M, et al. Thromb Haemost, 1993 Apr 1. PMID 8497848
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds.
      Title: An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood coagulation, common pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibrinogen alpha chain
    Names
    carboxy-terminal region
    fibrinogen A-alpha-chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      52924743..52933990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038688683.1 → XP_038544611.1  fibrinogen alpha chain isoform X1

      UniProtKB/TrEMBL
      A0A8C0MTI9, A0A8C0SEX7, A0A8I3NBI4, A0A8P0NAN3
      Related
      ENSCAFP00845013388.1, ENSCAFT00845017181.1
      Conserved Domains (4) summary
      cd00087
      Location:671 → 904
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:50 → 190
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:495 → 555
      Fibrinogen_aC; Fibrinogen alpha C domain
      cl11081
      Location:264 → 426
      dermokine

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      52179682..52188900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038496680.1 → XP_038352608.1  fibrinogen alpha chain isoform X1

      Conserved Domains (4) summary
      cd00087
      Location:671 → 904
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:50 → 190
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:495 → 555
      Fibrinogen_aC; Fibrinogen alpha C domain
      cl11081
      Location:264 → 426
      dermokine

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      52283995..52293478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623009.1 → XP_038478937.1  fibrinogen alpha chain isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      52601176..52608068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559074.1 → XP_038415002.1  fibrinogen alpha chain isoform X2

      UniProtKB/TrEMBL
      A0A8I3RXA2, A0A8P0SRG0
      Conserved Domains (3) summary
      pfam08702
      Location:50 → 190
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:480 → 540
      Fibrinogen_aC; Fibrinogen alpha C domain
      cl11081
      Location:264 → 411
      dermokine

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      52584628..52591483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532697.7 → XP_532697.3  fibrinogen alpha chain isoform X3

      UniProtKB/TrEMBL
      A0A8I3RXA2, A0A8P0SRG0
      Conserved Domains (3) summary
      pfam08702
      Location:50 → 190
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:480 → 540
      Fibrinogen_aC; Fibrinogen alpha C domain
      cl11081
      Location:264 → 411
      dermokine
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68213.1 GenPept UniProtKB/Swiss-Prot:P68213

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials