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    DPH2 diphthamide biosynthesis 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 475387, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DPH2provided by VGNC
    Official Full Name
    diphthamide biosynthesis 2provided by VGNC
    Primary source
    VGNC:VGNC:40068
    See related
    Ensembl:ENSCAFG00845028049
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DPH2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (16441825..16445608, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (16408187..16411963, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (16382434..16386210, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (16240687..16244460, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (16309692..16313468, complement)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 2 Neighboring gene ATPase H+ transporting V0 subunit b Neighboring gene importin 13 Neighboring gene uncharacterized LOC119868047 Neighboring gene artemin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; LOW QUALITY PROTEIN: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
    Names
    DPH2 homolog
    XP_003432052.1
    XP_022283758.1
    XP_038351881.1
    XP_038414257.1
    XP_038414258.1
    XP_038414259.1
    XP_038478146.1
    XP_038478147.1
    XP_038478148.1
    XP_038543874.1
    XP_038543875.1
    XP_038543876.1
    XP_532611.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      16441825..16445608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038687947.1 → XP_038543875.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QCB3, A0A8I3QFS2
      Related
      ENSCAFP00845038883.1, ENSCAFT00845049566.1
      Conserved Domains (1) summary
      cl19374
      Location:32 → 162
      Diphthamide_syn; Putative diphthamide synthesis protein

    2. XM_038687946.1 → XP_038543874.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KXV0, A0A8C0N7X7, A0A8C0QHB3
      Related
      ENSCAFP00845038858.1, ENSCAFT00845049530.1
      Conserved Domains (1) summary
      TIGR00322
      Location:32 → 366
      diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain

    3. XM_038687948.1 → XP_038543876.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X3

      Conserved Domains (1) summary
      cl19374
      Location:24 → 232
      Diphthamide_syn; Putative diphthamide synthesis protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      16240687..16244460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038495953.1 → XP_038351881.1  LOW QUALITY PROTEIN: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      16309692..16313468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038622219.1 → XP_038478147.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2

      Conserved Domains (1) summary
      cl19374
      Location:32 → 162
      Diphthamide_syn; Putative diphthamide synthesis protein

    2. XM_038622218.1 → XP_038478146.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1

      Conserved Domains (1) summary
      TIGR00322
      Location:32 → 366
      diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain

    3. XM_038622220.1 → XP_038478148.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X3

      Conserved Domains (1) summary
      cl19374
      Location:24 → 232
      Diphthamide_syn; Putative diphthamide synthesis protein

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      16382434..16386210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038558330.1 → XP_038414258.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QCB3, A0A8I3QFS2
      Conserved Domains (1) summary
      cl19374
      Location:32 → 162
      Diphthamide_syn; Putative diphthamide synthesis protein

    2. XM_038558329.1 → XP_038414257.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KXV0, A0A8C0N7X7, A0A8C0QHB3
      Conserved Domains (1) summary
      TIGR00322
      Location:32 → 366
      diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain

    3. XM_038558331.1 → XP_038414259.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X3

      Conserved Domains (1) summary
      cl19374
      Location:24 → 232
      Diphthamide_syn; Putative diphthamide synthesis protein

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      16408187..16411963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003432004.5 → XP_003432052.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QCB3, A0A8I3QFS2
      Conserved Domains (1) summary
      cl19374
      Location:32 → 162
      Diphthamide_syn; Putative diphthamide synthesis protein

    2. XM_532611.7 → XP_532611.2  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KXV0, A0A8C0N7X7, A0A8C0QHB3
      Conserved Domains (1) summary
      TIGR00322
      Location:32 → 366
      diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain

    3. XM_022428050.2 → XP_022283758.1  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X3

      Conserved Domains (1) summary
      cl19374
      Location:24 → 232
      Diphthamide_syn; Putative diphthamide synthesis protein
    Nucleotide Protein
    Heading Accession and Version

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