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    SHARPIN SHANK associated RH domain interactor [ Canis lupus familiaris (dog) ]

    Gene ID: 475122, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHARPINprovided by VGNC
    Official Full Name
    SHANK associated RH domain interactorprovided by VGNC
    Primary source
    VGNC:VGNC:49813
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SHARPIN in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 13 NC_051817.1 (38070379..38074493, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 13 NC_006595.4 (37557849..37561963, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 13 NC_049234.1 (38347294..38351410, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 13 NC_049273.1 (37742437..37746551, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 13 NC_049754.1 (37871117..37875231, complement)

    Chromosome 13 - NC_051817.1Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene cytochrome c1 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene WD repeat domain 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein linear polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of LUBAC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sharpin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051817.1 Reference ROS_Cfam_1.0

      Range
      38070379..38074493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038685320.1 → XP_038541248.1  sharpin

      Conserved Domains (4) summary
      smart00547
      Location:331 → 352
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:331 → 350
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:207 → 285
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam16764
      Location:7 → 119
      Sharpin_PH; Sharpin PH domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049273.1 Alternate UMICH_Zoey_3.1

      Range
      37742437..37746551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038493488.1 → XP_038349416.1  sharpin

      Conserved Domains (4) summary
      smart00547
      Location:331 → 352
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:331 → 350
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:207 → 285
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam16764
      Location:7 → 119
      Sharpin_PH; Sharpin PH domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049754.1 Alternate UNSW_CanFamBas_1.0

      Range
      37871117..37875231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038619711.1 → XP_038475639.1  sharpin

      Conserved Domains (4) summary
      smart00547
      Location:331 → 352
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:331 → 350
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:207 → 285
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam16764
      Location:7 → 119
      Sharpin_PH; Sharpin PH domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049234.1 Alternate UU_Cfam_GSD_1.0

      Range
      38347294..38351410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038555797.1 → XP_038411725.1  sharpin

      Conserved Domains (4) summary
      smart00547
      Location:331 → 352
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:331 → 350
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:207 → 285
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam16764
      Location:7 → 119
      Sharpin_PH; Sharpin PH domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006595.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37557849..37561963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532352.7 → XP_532352.4  sharpin

      Conserved Domains (4) summary
      smart00547
      Location:331 → 352
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:331 → 350
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd01799
      Location:207 → 285
      Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
      pfam16764
      Location:7 → 119
      Sharpin_PH; Sharpin PH domain
    Nucleotide Protein
    Heading Accession and Version

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