HLA-DRB1 MHC class II DLA DRB1 beta chain [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: HLA-DRB1
Gene description: MHC class II DLA DRB1 beta chain
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: DQB; DRB; DRB1; DRBB1; LA-DRB; DLA-DRB1; DLA-DRBB1
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	12	NC_051816.1 (2427792..2440407, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	12	NC_006594.4 (2300636..2313266, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	12	NC_049233.1 (2306389..2319034, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	12	NC_049272.1 (2150930..2163511, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	12	NC_049753.1 (2232117..2244754, complement)

Chromosome 12 - NC_051816.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

associated with gastric dilatation-volvulus in Great Danes
Title: Associations between gastric dilatation-volvulus in Great Danes and specific alleles of the canine immune-system genes DLA88, DRB1, and TLR5.
dogs homozygous at DRB1*69 [C/T] had a risk for developing Canine chronic superficial keratitis disease that was over four times the risk for heterozygotes.
Title: A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.
The haplotype DLADRB1* 01501/DQA1*00601/DQB1*00301 was significantly associated with chronic superficial keratitis (CSK) in German Shepherd dogs, and homozygosity of MHC class II increased risk for CSK.
Title: MHC class II risk haplotype associated with canine chronic superficial keratitis in German Shepherd dogs.
Two new DLA-DRB1 alleles were identified.
Title: Evaluation of the class II region of the major histocompatibility complex of the greyhound with the genomic matching technique and sequence-based typing.
data do not provide evidence for involvement of DLA-DRB1 in degenerative myelopathy
Title: Alleles of DLA-DRB1 are not unique in German Shepherd dogs having degenerative myelopathy.
analysis of distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 among dog breeds
Title: Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American Kennel Club breeds.

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General gene information

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Markers

DLA-DQA (e-PCR)
- UniSTS:262979

DLA-DRB1 (e-PCR)
- UniSTS:262981

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in peptide antigen assembly with MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DLA class II histocompatibility antigen, DR-1 beta chain

Names: DLA DRBB1 beta chain; DLA class II antigen; DLA class II beta chain; DLA-DR beta; MHC class II DLA-DR-beta-1; MHC class II DLA-DRB; MHC class II DR beta 1; MHC class II antigen beta chain; major histocompatability complex class II DLA-DRB1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014768.1 → NP_001014768.1 DLA class II histocompatibility antigen, DR-1 beta chain precursor

See identical proteins and their annotated locations for NP_001014768.1

Status: PROVISIONAL

Source sequence(s)

M29611

UniProtKB/Swiss-Prot

P18470

UniProtKB/TrEMBL

A0A7R6QDR2

Conserved Domains (2) summary

cd05766
Location:126 → 219

IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain

pfam00969
Location:42 → 116

MHC_II_beta; Class II histocompatibility antigen, beta domain