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    P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 474672, updated on 17-Aug-2024

    Summary

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    Official Symbol
    P4HA2provided by VGNC
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 2provided by VGNC
    Primary source
    VGNC:VGNC:44223
    See related
    Ensembl:ENSCAFG00845009961
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See P4HA2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (21300346..21333655, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (19310369..19350017, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (20509393..20542685, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (20019425..20052694, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (19867545..19900820, complement)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase long chain family member 6 Neighboring gene colony stimulating factor 2 Neighboring gene U6 spliceosomal RNA Neighboring gene PDZ and LIM domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-2
    Names
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
    XP_005626566.1
    XP_005626567.1
    XP_013973184.1
    XP_038345955.1
    XP_038345956.1
    XP_038345957.1
    XP_038345958.1
    XP_038345959.1
    XP_038408035.1
    XP_038408036.1
    XP_038408037.1
    XP_038408038.1
    XP_038408039.1
    XP_038471894.1
    XP_038471895.1
    XP_038471896.1
    XP_038471897.1
    XP_038471898.1
    XP_038516798.1
    XP_038537391.1
    XP_038537392.1
    XP_038537393.1
    XP_038537394.1
    XP_038537395.1
    XP_850109.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      21300346..21333655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038681464.1 → XP_038537392.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Related
      ENSCAFP00845013633.1, ENSCAFT00845017515.1
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038681463.1 → XP_038537391.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038681466.1 → XP_038537394.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N641, A0A8C0R125, A0A8C0RYL5
      Related
      ENSCAFP00845013670.1, ENSCAFT00845017563.1
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038681465.1 → XP_038537393.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038681467.1 → XP_038537395.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RYL5
      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      20019425..20052694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038490028.1 → XP_038345956.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038490027.1 → XP_038345955.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038490030.1 → XP_038345958.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038490029.1 → XP_038345957.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038490031.1 → XP_038345959.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      19867545..19900820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038615967.1 → XP_038471895.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038615966.1 → XP_038471894.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038615969.1 → XP_038471897.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038615968.1 → XP_038471896.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038615970.1 → XP_038471898.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      20509393..20542685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038552108.1 → XP_038408036.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038552107.1 → XP_038408035.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038552110.1 → XP_038408038.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N641, A0A8C0R125, A0A8C0RYL5
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038552109.1 → XP_038408037.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_038552111.1 → XP_038408039.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RYL5
      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19310369..19350017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005626510.3 → XP_005626567.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_005626567.1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_005626509.4 → XP_005626566.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      See identical proteins and their annotated locations for XP_005626566.1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_845016.7 → XP_850109.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0N641, A0A8C0R125, A0A8C0RYL5
      Conserved Domains (2) summary
      smart00702
      Location:346 → 517
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_038660870.1 → XP_038516798.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0N6E8, A0A8C0RYL5, A0A8I3NFI3
      Conserved Domains (2) summary
      smart00702
      Location:346 → 519
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    5. XM_014117709.3 → XP_013973184.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0RYL5
      Conserved Domains (2) summary
      smart00702
      Location:346 → 539
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 104
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein
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