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    KCNN2 potassium calcium-activated channel subfamily N member 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 474640, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KCNN2provided by VGNC
    Official Full Name
    potassium calcium-activated channel subfamily N member 2provided by VGNC
    Primary source
    VGNC:VGNC:42285
    See related
    Ensembl:ENSCAFG00845010795
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See KCNN2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (4259813..4403473)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (4114348..4574043)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (4237744..4692269)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (3914674..4366142)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (4295183..4439054)

    Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119880189 Neighboring gene probable ATP-dependent RNA helicase DDX43 Neighboring gene uncharacterized LOC119880190 Neighboring gene uncharacterized LOC119874019 Neighboring gene tripartite motif containing 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium. Hsueh CH, et al. Heart Rhythm, 2013 Jun. PMID 23376397, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel protein 2; LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2
    Names
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
    small conductance calcium-activated potassium channel protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051815.1 Reference ROS_Cfam_1.0

      Range
      4259813..4403473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038681183.1 → XP_038537111.1  LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SBF9
      Related
      ENSCAFP00845014933.1, ENSCAFT00845019115.1
      Conserved Domains (3) summary
      smart01053
      Location:686 → 761
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:398 → 505
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:593 → 672
      Ion_trans_2; Ion channel

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049271.1 Alternate UMICH_Zoey_3.1

      Range
      3914674..4366142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038489786.1 → XP_038345714.1  small conductance calcium-activated potassium channel protein 2 isoform X2

      Conserved Domains (3) summary
      smart01053
      Location:216 → 291
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:1 → 35
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:123 → 202
      Ion_trans_2; Ion channel

    2. XM_038489785.1 → XP_038345713.1  small conductance calcium-activated potassium channel protein 2 isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

      Range
      4295183..4439054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038615716.1 → XP_038471644.1  LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2 isoform X1

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

      Range
      4237744..4692269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038551827.1 → XP_038407755.1  small conductance calcium-activated potassium channel protein 2 isoform X3

      Conserved Domains (3) summary
      smart01053
      Location:216 → 291
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:1 → 35
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:123 → 202
      Ion_trans_2; Ion channel

    2. XM_038551826.1 → XP_038407754.1  small conductance calcium-activated potassium channel protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0SBF9

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      4114348..4574043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662673.1 → XP_038518601.1  small conductance calcium-activated potassium channel protein 2 isoform X4

      Conserved Domains (3) summary
      smart01053
      Location:216 → 291
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:1 → 35
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:123 → 202
      Ion_trans_2; Ion channel

    2. XM_022425125.2 → XP_022280833.1  small conductance calcium-activated potassium channel protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8P0S674
      Conserved Domains (3) summary
      smart01053
      Location:684 → 759
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:396 → 503
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:591 → 670
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials