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    Adgre4 adhesion G protein-coupled receptor E4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 450235, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Adgre4provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor E4provided by RGD
    Primary source
    RGD:1359641
    See related
    EnsemblRapid:ENSRNOG00000050325 AllianceGenome:RGD:1359641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Emr4; Emr4p; Adgre4p
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Orthologous to human ADGRE4P (adhesion G protein-coupled receptor E4, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 175.3), Liver (RPKM 27.5) and 4 other tissues See more
    Orthologs
    cow mouse all
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    Genomic context

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    See Adgre4 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (10085258..10240346)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (9758106..9901908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (8056034..8200262)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene protection of telomeres 1B Neighboring gene Nedd4 binding protein 1, pseudogene 2 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 138 Neighboring gene uncharacterized LOC134480472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The EGF-TM7 family of the rat. Hamann J. Immunogenetics, 2004 Dec. PMID 15578266
    2. EMR4, a novel epidermal growth factor (EGF)-TM7 molecule up-regulated in activated mouse macrophages, binds to a putative cellular ligand on B lymphoma cell line A20. Stacey M, et al. J Biol Chem, 2002 Aug 9. PMID 12023293
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like module-containing mucin-like hormone receptor-like 4
    Names
    EGF-like module containing, mucin-like, hormone receptor-like 4
    EGF-like module containing, mucin-like, hormone receptor-like sequence 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007558.2 → NP_001007559.1  EGF-like module-containing mucin-like hormone receptor-like 4 precursor

      See identical proteins and their annotated locations for NP_001007559.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K538, Q5Y4N7
      Related
      ENSRNOP00000106052.1, ENSRNOT00000138087.1
      Conserved Domains (5) summary
      smart00179
      Location:75 → 103
      EGF_CA; Calcium-binding EGF-like domain
      pfam01825
      Location:287 → 329
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:209 → 261
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:342 → 367
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:342 → 606
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      10085258..10240346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267566.1 → XP_063123636.1  EGF-like module-containing mucin-like hormone receptor-like 4 isoform X1

      Related
      ENSRNOP00000073279.3, ENSRNOT00000081513.3

    2. XM_039084035.2 → XP_038939963.1  EGF-like module-containing mucin-like hormone receptor-like 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K538
      Conserved Domains (4) summary
      smart00179
      Location:75 → 103
      EGF_CA; Calcium-binding EGF-like domain
      pfam16489
      Location:209 → 261
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:283 → 310
      7tm_GPCRs; TM helix 3 [structural motif]
      cl28897
      Location:277 → 482
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_063267567.1 → XP_063123637.1  EGF-like module-containing mucin-like hormone receptor-like 4 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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