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    mettl1 methyltransferase 1, tRNA methylguanosine [ Danio rerio (zebrafish) ]

    Gene ID: 449779, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mettl1provided by ZNC
    Official Full Name
    methyltransferase 1, tRNA methylguanosineprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-24
    See related
    Ensembl:ENSDARG00000076518 AllianceGenome:ZFIN:ZDB-GENE-041010-24
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:103636
    Summary
    Predicted to enable tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in nucleus. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mettl1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (296438..322249)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (269013..295751)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene POC1 centriolar protein A Neighboring gene neuropeptide FF-amide peptide precursor like Neighboring gene solute carrier family 11 member 2 Neighboring gene cytochrome P450, family 27, subfamily B, polypeptide 1 Neighboring gene si:ch211-159e12.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(46)-N7)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA (guanine-N7)-methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA (guanine-N7)-methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of tRNA (m7G46) methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of tRNA methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine-N(7)-)-methyltransferase
    Names
    mRNA (guanine-N(7)-)-methyltransferase
    methyltransferase like 1
    miRNA (guanine-N(7)-)-methyltransferase
    NP_001005952.1
    XP_005155730.1
    XP_005155731.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005952.1 → NP_001005952.1  tRNA (guanine-N(7)-)-methyltransferase

      See identical proteins and their annotated locations for NP_001005952.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083450
      UniProtKB/TrEMBL
      B2GRE1
      Related
      ENSDARP00000128994.2, ENSDART00000154425.3
      Conserved Domains (2) summary
      COG0220
      Location:6 → 236
      TrmB; tRNA G46 methylase TrmB [Translation, ribosomal structure and biogenesis]
      pfam02390
      Location:54 → 231
      Methyltransf_4; Putative methyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      296438..322249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155673.5 → XP_005155730.1  tRNA (guanine-N(7)-)-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_005155730.1

      UniProtKB/Swiss-Prot
      A7MCF3, F1QU80, Q5XJ57
      Related
      ENSDARP00000101871.2, ENSDART00000109091.4
      Conserved Domains (1) summary
      pfam02390
      Location:54 → 231
      Methyltransf_4; Putative methyltransferase

    2. XM_005155674.4 → XP_005155731.1  tRNA (guanine-N(7)-)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2M5
      Conserved Domains (1) summary
      pfam02390
      Location:21 → 184
      Methyltransf_4; Putative methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XJ57.2 GenPept UniProtKB/Swiss-Prot:Q5XJ57

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