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    HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 448791, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HCN2provided by VGNC
    Official Full Name
    hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2provided by VGNC
    Primary source
    VGNC:VGNC:81268
    See related
    Ensembl:ENSCAFG00845015054
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See HCN2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (58663358..58681919, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (57722746..57741278, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (58400096..58421283, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (57717402..57735597, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (58196864..58215545, complement)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 22 Neighboring gene RNA polymerase mitochondrial Neighboring gene basigin Neighboring gene uncharacterized LOC102156540

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation. Li YD, et al. Med Sci Monit, 2014 Nov 14. PMID 25404650, Free PMC Article
    2. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Zicha S, et al. Cardiovasc Res, 2005 Jun 1. PMID 15914112

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There was a reversal in the local tissue distribution of HCN2 and HCN4 channel mRNA and protein, a decrease in sinoatrial node expression, and increase in atrial and pulmonary vein expression with age.
      Title: Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
    Names
    cardiac hyperpolarization-activated current subunit 2
    hyperpolarization activated cyclic nucleotide gated potassium channel 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      58663358..58681919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038429384.1 → XP_038285312.1  LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I3NR07
      Related
      ENSCAFP00845021208.1, ENSCAFT00845026941.1
      Conserved Domains (2) summary
      PLN03192
      Location:151 → 689
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:545 → 653
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      57717402..57735597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038504910.1 → XP_038360838.1  LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      58196864..58215545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038629519.1 → XP_038485447.1  LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      58400096..58421283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038565398.1 → XP_038421326.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I3NR07

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      57722746..57741278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014121847.3 → XP_013977322.2  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I3NR07, A0A8P0NKU2
      Conserved Domains (2) summary
      PLN03192
      Location:153 → 691
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:547 → 655
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. XM_038455447.1 → XP_038311375.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0RPQ0
      Conserved Domains (2) summary
      PLN03192
      Location:153 → 649
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:547 → 655
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    Nucleotide Protein
    Heading Accession and Version

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