ildr1b immunoglobulin-like domain containing receptor 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ildr1bprovided by ZNC
Official Full Name: immunoglobulin-like domain containing receptor 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-72
See related: Ensembl:ENSDARG00000040910 AllianceGenome:ZFIN:ZDB-GENE-040912-72
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ildr1; fc95b03; wu:fc95b03; zgc:101133
Summary: Predicted to enable high-density lipoprotein particle receptor activity. Acts upstream of or within posterior lateral line neuromast deposition and semicircular canal development. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adenohypophyseal placode; adenohypophysis; endoderm; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 42. Orthologous to human ILDR1 (immunoglobulin like domain containing receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (34260602..34269066, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (34451417..34459881, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

First evidence for the mechanism of Ildr1b on hearing in vivo and sheds light on the pathology of DFNB42.
Title: Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables high-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast deposition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: immunoglobulin-like domain-containing receptor 1b

Names: immunoglobulin-like domain containing receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004642.2 → NP_001004642.2 immunoglobulin-like domain-containing receptor 1b precursor

Status: VALIDATED

Source sequence(s)

BX294189, EH440533, EH530787, EH568753

Related

ENSDARP00000059954.4, ENSDART00000059955.5

Conserved Domains (1) summary

cl11960
Location:39 → 165

Ig; Immunoglobulin domain