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    bmpr1ab bone morphogenetic protein receptor, type IAb [ Danio rerio (zebrafish) ]

    Gene ID: 447846, updated on 28-Sep-2024

    Summary

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    Official Symbol
    bmpr1abprovided by ZNC
    Official Full Name
    bone morphogenetic protein receptor, type IAbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-150
    See related
    Ensembl:ENSDARG00000105045 AllianceGenome:ZFIN:ZDB-GENE-040912-150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92227; wu:fe05b06; wu:fe06e10
    Summary
    Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway; circulatory system development; and regionalization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blastoderm; blastodisc; cardinal system; margin; and ovarian follicle. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See bmpr1ab in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25950650..26022663, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25859474..25931303, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene synuclein, gamma b (breast cancer-specific protein 1) Neighboring gene multimerin 2b Neighboring gene LIM domain binding 3b Neighboring gene opsin 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Kim JD, et al. Mol Cells, 2014 Mar. PMID 24608800, Free PMC Article
    2. Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish. Allen RS, et al. Elife, 2020 Sep 8. PMID 32897189, Free PMC Article
    3. Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling. Niu X, et al. Curr Biol, 2020 Sep 7. PMID 32649909, Free PMC Article
    4. Bmp signaling exerts opposite effects on cardiac differentiation. de Pater E, et al. Circ Res, 2012 Feb 17. PMID 22247485, Free PMC Article
    5. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Little SC, et al. Nat Cell Biol, 2009 May. PMID 19377468, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BMP heterodimers signal via distinct type I receptor class functions.
      Title: BMP heterodimers signal via distinct type I receptor class functions.
    2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.
      Title: Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph vessel development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein receptor, type IAb
    Names
    alk3b
    bone morphogenetic protein receptor, type 1ab
    bone morphogenetic protein receptor, type IA,b
    NP_001004585.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004585.2 → NP_001004585.2  bone morphogenetic protein receptor, type IAb precursor

      Status: VALIDATED

      Source sequence(s)
      BX957331
      Related
      ENSDARP00000141520.1, ENSDART00000166769.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      25950650..26022663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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