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    lolal lola like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44703, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lolalprovided by FlyBase
    Official Full Name
    lola likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022238
    Locus tag
    Dmel_CG5738
    See related
    AllianceGenome:FB:FBgn0022238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    25/12; anon-EST:fe3D3; anon-WO0172774.186; ban; Ban; bat; CG5738; Dmel\CG5738; EP0647; EP647; l(2)k02512; l(2)kO2512; Lolal; LOLAL
    Summary
    Enables DNA binding activity; POZ domain binding activity; and protein homodimerization activity. Involved in several processes, including gland development; regulation of gene expression; and tracheal outgrowth, open tracheal system. Located in condensed nuclear chromosome and polytene chromosome. Part of PcG protein complex. Is expressed in several structures, including anterior endoderm anlage; extended germ band embryo; female-specific anatomical entity; presumptive embryonic/larval system; and trunk ectoderm. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lolal in Genome Data Viewer
    Location:
    55B9-55B9; 2-84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18154095..18158192, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14041600..14045697, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene adipose Neighboring gene uncharacterized protein Neighboring gene Nausicaa Neighboring gene Nucleoporin 75kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. Roignant JY, et al. RNA, 2003 Mar. PMID 12592004, Free PMC Article
    2. Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development. Laurichesse Q, et al. Front Cell Dev Biol, 2021. PMID 34977007, Free PMC Article
    3. Drosophila retinal pigment cell death is regulated in a position-dependent manner by a cell memory gene. Dos-Santos N, et al. Int J Dev Biol, 2008. PMID 18033669
    4. Silence of yki by miR-7 regulates the Hippo pathway. Yu X, et al. Biochem Biophys Res Commun, 2020 Nov 12. PMID 32888651
    5. Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors. Bartoletti M, et al. PLoS One, 2012. PMID 23185495, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we report that a striking common feature of a reduction in psq, Trl and batman gene dosage is an increase in the number of ovarioles
      Title: Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors.
    2. batman belongs to a subset of the Polycomb/trithorax group of genes that includes Trithorax-like, whose products are involved in both activation and repression of homeotic genes.
      Title: batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables POZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval lymph gland hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tracheal outgrowth, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lola like
    Names
    CG5738-PA
    CG5738-PB
    CG5738-PC
    CG5738-PD
    CG5738-PE
    CG5738-PF
    CG5738-PG
    CG5738-PH
    anon-fast-evolving-3D3
    batman
    lola-like
    lolal-PA
    lolal-PB
    lolal-PC
    lolal-PD
    lolal-PE
    lolal-PF
    lolal-PG
    lolal-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18154095..18158192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080039.4 → NP_524778.1  lola like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Related
      FBpp0085956
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    2. NM_001259473.2 → NP_001246402.1  lola like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    3. NM_166270.2 → NP_725756.1  lola like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725756.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Related
      FBpp0085955
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    4. NM_166271.3 → NP_725757.1  lola like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Related
      FBpp0085957
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    5. NM_001299635.1 → NP_001286564.1  lola like, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    6. NM_166272.3 → NP_725758.1  lola like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Related
      FBpp0085958
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    7. NM_001259474.2 → NP_001246403.1  lola like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    8. NM_001169715.2 → NP_001163186.1  lola like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZN1, B7YZR8, C7LAH2, Q7KRI2
      UniProtKB/TrEMBL
      E1JGK7
      Conserved Domains (1) summary
      cd18315
      Location:32 → 115
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGK7 E1JGK7
    Q7KRI2.1 Q7KRI2

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