PLA2G1B phospholipase A2 group IB [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PLA2G1Bprovided by VGNC
Official Full Name: phospholipase A2 group IBprovided by VGNC
Primary source: VGNC:VGNC:111128
See related: Ensembl:ENSSSCG00000029501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PLA2; sPLA(2)-IB
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in lung (RPKM 12.4), mixtures (RPKM 2.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	14	NC_010456.5 (40314520..40322315, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	14	NC_010456.4 (42821332..42829127)

Chromosome 14 - NC_010456.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, the inhibitory activity of 1-napthaleneacetic acid (NAA) against porcine pancreatic PLA2 has been explained through isothermal titration calorimetry and enzyme kinetics studies.
Title: Crystal structure of phospholipase A(2) in complex with 1-naphthaleneacetic acid.
Equilibrium unfolding of porcine pancreatic phospholipase A2 was monitored using multiple approaches. An unusually broad unfolding transition at remarkably high denaturant concentration was observed.
Title: Native state dynamics affects the folding transition of porcine pancreatic phospholipase A2.
Interfacial activation of pig pancreatic IB phospholipase A(2) (PLA2) is modeled in terms of the three discrete premicellar complexes (E(i)(#), i = 1, 2, or 3) consecutively formed by the cooperative binding of a monodisperse amphiphile to the i-face
Title: Thermodynamic reciprocity of the inhibitor binding to the active site and the interface binding region of IB phospholipase A2.
An increased sPLA(2) activity and a reduced inhibition may play an important role in the pathogenesis of ischemia-reperfusion injury of non-heart-beating donor liver grafts.
Title: Increased serum phospholipase A2 activity after non-heart-beating donor liver transplantation and association with ischemia-reperfusion injury.
Results show that the decylsulfate epitope for the successive E i (#) complexes increasingly resembles the micellar complex formed by the binding of PLA2 to preformed micelles.
Title: Contiguous binding of decylsulfate on the interface-binding surface of pancreatic phospholipase A2.
MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2
Title: MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2.
Porcine pancreatic PLA(2) shows a long lag phase of several hours during which the enzyme binds to the bilayer surface, but only 5+/-3% of the lipids react before the onset of rapid hydrolysis.
Title: Distribution of reaction products in phospholipase A2 hydrolysis.
Results describe the structural basis for bile salt inhibition of pancreatic phospholipase A2.
Title: Structural basis for bile salt inhibition of pancreatic phospholipase A2.
Porcine group IB secretory phospholipase A2 (PLA2G1B) stimulates the expression and secretion of CXC chemokine ligand 8 (CXCL8) in human neutrophils without affecting other proinflammatory cytokines.
Title: Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phospholipase A2, major isoenzyme

Names: group IB phospholipase A2; group IB secretory phospholipase A(2); phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2, group IB (pancreas)

NP_001004037.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.