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    g6pc1a.1 glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 445118, updated on 17-Sep-2024

    Summary

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    Official Symbol
    g6pc1a.1provided by ZNC
    Official Full Name
    glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031001-4
    See related
    Ensembl:ENSDARG00000031616 AllianceGenome:ZFIN:ZDB-GENE-031001-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    g6pc; cb822; g6pca; g6pca.1; zgc:92368
    Summary
    Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in gluconeogenesis and glucose 6-phosphate metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in digestive system; liver; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See g6pc1a.1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6023490..6033854, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5989885..6000335, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene si:ch211-131k2.2 Neighboring gene K(lysine) acetyltransferase 7b Neighboring gene prostaglandin E synthase 3 like Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 2 Neighboring gene alanyl-tRNA synthetase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. Wang Y, et al. Gen Comp Endocrinol, 2015 Apr 1. PMID 25745818
    2. Programming effects of high-carbohydrate feeding of larvae on adult glucose metabolism in zebrafish, Danio rerio. Fang L, et al. Br J Nutr, 2014 Mar 14. PMID 24112146
    3. Liver toxicity of macrolide antibiotics in zebrafish. Zhang MQ, et al. Toxicology, 2020 Aug. PMID 32454074
    4. Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish. Brun NR, et al. Commun Biol, 2019. PMID 31646185, Free PMC Article
    5. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. Li M, et al. J Endocrinol, 2015 Nov. PMID 26446275, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables glucose-6-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
    Names
    glucose-6-phosphatase a, catalytic, tandem duplicate 1
    glucose-6-phosphatase, catalytic
    NP_001003512.2
    NP_001303265.1
    XP_009304709.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003512.2 → NP_001003512.2  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX248126, EH484431, EH520605
      UniProtKB/TrEMBL
      A0A8M1N1J9, F1Q559
      Related
      ENSDARP00000116534.1, ENSDART00000139419.3
      Conserved Domains (2) summary
      COG0671
      Location:35 → 197
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03381
      Location:38 → 261
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    2. NM_001316336.1 → NP_001303265.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BX248126, EH484431, EH488933, EH494161, EH520605
      UniProtKB/TrEMBL
      A0A8M1P7S6, E7F5Z2
      Related
      ENSDARP00000030904.7, ENSDART00000032050.8
      Conserved Domains (1) summary
      cd03381
      Location:38 → 231
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      6023490..6033854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306434.4 → XP_009304709.1  glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 isoform X1

      See identical proteins and their annotated locations for XP_009304709.1

      UniProtKB/TrEMBL
      A0A8M1N1J9, F1Q559
      Conserved Domains (2) summary
      COG0671
      Location:35 → 197
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03381
      Location:38 → 261
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...
    Nucleotide Protein Strain
    Heading Accession and Version

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