crhbp corticotropin releasing hormone binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crhbpprovided by ZNC
Official Full Name: corticotropin releasing hormone binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-196
See related: Ensembl:ENSDARG00000024831 AllianceGenome:ZFIN:ZDB-GENE-040801-196
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: crfbp; zgc:91905
Summary: Predicted to enable corticotropin-releasing hormone binding activity. Predicted to be involved in hormone-mediated signaling pathway; negative regulation of corticotropin secretion; and negative regulation of corticotropin-releasing hormone receptor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; neurons; and retina. Human ortholog(s) of this gene implicated in mental depression. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (7823146..7832352)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (7217925..7227131)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: corticotropin-releasing factor-binding protein

Names: CRF-BP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.