LTBP4 latent transforming growth factor beta binding protein 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LTBP4provided by VGNC
Official Full Name: latent transforming growth factor beta binding protein 4provided by VGNC
Primary source: VGNC:VGNC:42859
See related: Ensembl:ENSCAFG00845003336
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (113722679..113749021, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (112526364..112552684, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (113908479..113934829, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (113282295..113308625, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (112913954..112940503, complement)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the combined expression patterns of BMP2, LTBP4, and DERL1 (Derlin-1) correctly classified each individual tumor as benign or malignant.
Title: The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors.

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General gene information

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Markers

MARC_8055-8056:996688248:1 (e-PCR)
- UniSTS:269880

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: latent-transforming growth factor beta-binding protein 4; LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051805.1 Reference ROS_Cfam_1.0

Range

113722679..113749021 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038656939.1 → XP_038512867.1 latent-transforming growth factor beta-binding protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0M3I2, A0A8I3RSV2, A0A8P0N7S6

Related

ENSCAFP00845004874.1, ENSCAFT00845006128.1

Conserved Domains (5) summary

smart00179
Location:832 → 864

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:669 → 706

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:750 → 790

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:421 → 463

TB; TB domain

pfam12662
Location:565 → 588

cEGF; Complement Clr-like EGF-like
XM_038656941.1 → XP_038512869.1 latent-transforming growth factor beta-binding protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I3RSW0, A0A8P0PFR4

Related

ENSCAFP00845004934.1, ENSCAFT00845006204.1

Conserved Domains (5) summary

smart00179
Location:759 → 791

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:596 → 633

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:677 → 717

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:348 → 390

TB; TB domain

pfam12662
Location:492 → 515

cEGF; Complement Clr-like EGF-like
XM_038656940.1 → XP_038512868.1 latent-transforming growth factor beta-binding protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I3RSW0, A0A8P0PFR4

Conserved Domains (5) summary

smart00179
Location:770 → 802

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:596 → 633

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:677 → 717

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:348 → 390

TB; TB domain

pfam12662
Location:492 → 515

cEGF; Complement Clr-like EGF-like

Alternate UMICH_Zoey_3.1

Genomic

NC_049261.1 Alternate UMICH_Zoey_3.1

Range

113282295..113308625 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038468105.1 → XP_038324033.1 latent-transforming growth factor beta-binding protein 4 isoform X1
XM_038468107.1 → XP_038324035.1 latent-transforming growth factor beta-binding protein 4 isoform X3
XM_038468106.1 → XP_038324034.1 latent-transforming growth factor beta-binding protein 4 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049742.1 Alternate UNSW_CanFamBas_1.0

Range

112913954..112940503 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038593117.1 → XP_038449045.1 latent-transforming growth factor beta-binding protein 4 isoform X1
XM_038593119.1 → XP_038449047.1 latent-transforming growth factor beta-binding protein 4 isoform X3
XM_038593118.1 → XP_038449046.1 latent-transforming growth factor beta-binding protein 4 isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049222.1 Alternate UU_Cfam_GSD_1.0

Range

113908479..113934829 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038528846.1 → XP_038384774.1 LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0SAB4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

112526364..112552684 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_533664.6 → XP_533664.3 latent-transforming growth factor beta-binding protein 4 isoform X1

UniProtKB/TrEMBL

A0A8C0M3I2, A0A8I3RSV2, A0A8P0N7S6

Conserved Domains (5) summary

smart00179
Location:832 → 864

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:669 → 706

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:750 → 790

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:421 → 463

TB; TB domain

pfam12662
Location:565 → 588

cEGF; Complement Clr-like EGF-like
XM_038448161.1 → XP_038304089.1 latent-transforming growth factor beta-binding protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I3RSW0, A0A8P0PFR4

Conserved Domains (5) summary

smart00179
Location:759 → 791

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:596 → 633

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:677 → 717

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:348 → 390

TB; TB domain

pfam12662
Location:492 → 515

cEGF; Complement Clr-like EGF-like
XM_038448130.1 → XP_038304058.1 latent-transforming growth factor beta-binding protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I3RSW0, A0A8P0PFR4

Conserved Domains (5) summary

smart00179
Location:770 → 802

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:596 → 633

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:677 → 717

EGF_CA; Calcium-binding EGF domain

pfam00683
Location:348 → 390

TB; TB domain

pfam12662
Location:492 → 515

cEGF; Complement Clr-like EGF-like