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    SHMT1 serine hydroxymethyltransferase 1 [ Ovis aries (sheep) ]

    Gene ID: 443544, updated on 10-Oct-2024

    Summary

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    Gene symbol
    SHMT1
    Gene description
    serine hydroxymethyltransferase 1
    See related
    EnsemblRapid:ENSOARG00020026362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    SHMT; SHMT2
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (34072580..34099277)

    Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene uncharacterized LOC121820593 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene DNA topoisomerase III alpha Neighboring gene mitochondrial elongation factor 2 Neighboring gene FLII actin remodeling protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase. Jala VR, et al. Indian J Biochem Biophys, 2003 Aug. PMID 22900314
    2. The primary structure of sheep liver cytosolic serine hydroxymethyltransferase and an analysis of the evolutionary relationships among serine hydroxymethyltransferases. Usha R, et al. Biochim Biophys Acta, 1994 Jan 11. PMID 8305478
    3. cDNA cloning, overexpression in Escherichia coli, purification and characterization of sheep liver cytosolic serine hydroxymethyltransferase. Jagath-Reddy J, et al. Eur J Biochem, 1995 Jun 1. PMID 7607226
    4. Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply. Lewis RM, et al. J Clin Endocrinol Metab, 2005 Mar. PMID 15598699

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. characterization of sheep liver cytosolic serine hydroxymethyltransferase
      Title: Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.
    2. The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species.
      Title: Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, cytosolic
    Names
    cytosolic serine hydroxymethyltransferase
    glycine hydroxymethyltransferase
    serine hydroxymethyl transferase
    serine hydroxymethyltransferase 2 (mitochondrial)
    serine methylase
    NP_001009469.1
    XP_027829756.1
    XP_027829757.1
    XP_060250690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009469.1 → NP_001009469.1  serine hydroxymethyltransferase, cytosolic

      See identical proteins and their annotated locations for NP_001009469.1

      Status: PROVISIONAL

      Source sequence(s)
      X80024
      UniProtKB/Swiss-Prot
      P35623
      UniProtKB/TrEMBL
      A0A6P7EF41, W5QB21
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      34072580..34099277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027973956.2 → XP_027829757.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/Swiss-Prot
      P35623
      UniProtKB/TrEMBL
      A0A6P7EF41, W5QB21
      Related
      ENSOARP00020034441.1, ENSOART00020041479.2
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    2. XM_027973955.2 → XP_027829756.1  serine hydroxymethyltransferase, cytosolic isoform X1

      UniProtKB/Swiss-Prot
      P35623
      UniProtKB/TrEMBL
      A0A6P7EF41, W5QB21
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    3. XM_060394707.1 → XP_060250690.1  serine hydroxymethyltransferase, cytosolic isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35623.3 GenPept UniProtKB/Swiss-Prot:P35623

    Gene LinkOut

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