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    HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Ovis aries (sheep) ]

    Gene ID: 443409, updated on 5-Mar-2024

    Summary

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    Gene symbol
    HSD11B1
    Gene description
    hydroxysteroid 11-beta dehydrogenase 1
    See related
    EnsemblRapid:ENSOARG00020020417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See HSD11B1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 12 NC_056065.1 (73023453..73061521, complement)

    Chromosome 12 - NC_056065.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132657531 Neighboring gene chromosome 12 C1orf74 homolog Neighboring gene interferon regulatory factor 6 Neighboring gene TRAF3 interacting protein 3 Neighboring gene laminin subunit beta 3 Neighboring gene G0/G1 switch 2 Neighboring gene uncharacterized LOC114117304 Neighboring gene calcium/calmodulin dependent protein kinase IG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056065.1 Chromosome 12 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development. Yang K, et al. Endocrinology, 1992 Nov. PMID 1425412
    2. Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins. Dorniak P, et al. Biol Reprod, 2012 Apr. PMID 22205698
    3. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation. Brooks K, et al. Biol Reprod, 2015 Aug. PMID 26085523
    4. Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation. Gentili S, et al. Biol Reprod, 2009 Jun. PMID 19208549, Free PMC Article
    5. HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau. Simmons RM, et al. Biol Reprod, 2010 Jan. PMID 19696010

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results support the idea that the effects of HSD11B1-derived cortisol on conceptus elongation are indirectly mediated by the endometrium and are not directly mediated through GR in the trophectoderm
      Title: Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation.
    2. Studies support the idea that IFNT and PGs from the conceptus regulate endometrial HSD11B1 expression and activity that regenerates bioactive cortisol in the ovine uterus during early pregnancy to influence endometrial functions and conceptus elongation.
      Title: Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins.
    3. Endometrial epithelial HSD11B1 expression is induced by progesterone as well as stimulated by interferon tau and PTGS2-derived prostaglandins.
      Title: HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.
    4. hepatic expression of 11beta-hydroxysteroid dehydrogenase type 1 increased in placental restriction-hypoxic reduced liver growth
      Title: Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in steroid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    11-beta-hydroxysteroid dehydrogenase 1
    Names
    11-DH
    11-beta-HSD1
    7-oxosteroid reductase
    corticosteroid 11-beta-dehydrogenase isozyme 1
    NP_001009395.1
    XP_042112784.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009395.2 → NP_001009395.1  11-beta-hydroxysteroid dehydrogenase 1

      See identical proteins and their annotated locations for NP_001009395.1

      Status: PROVISIONAL

      Source sequence(s)
      X69561
      UniProtKB/Swiss-Prot
      P51975
      Related
      ENSOARP00020026017.1, ENSOART00020031471.2
      Conserved Domains (2) summary
      pfam00106
      Location:35 → 230
      adh_short; short chain dehydrogenase
      cl21454
      Location:32 → 279
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056065.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      73023453..73061521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042256850.2 → XP_042112784.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:32 → 231
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51975.3 GenPept UniProtKB/Swiss-Prot:P51975

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials