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    IDH1 isocitrate dehydrogenase (NADP(+)) 1 [ Ovis aries (sheep) ]

    Gene ID: 443257, updated on 5-Mar-2024

    Summary

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    Gene symbol
    IDH1
    Gene description
    isocitrate dehydrogenase (NADP(+)) 1
    See related
    EnsemblRapid:ENSOARG00020016933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    IDPc; NADP-CICDH
    Orthologs
    human mouse all
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    Genomic context

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    See IDH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (210312166..210332222, complement)

    Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene gamma-crystallin A Neighboring gene chromosome 2 C2orf80 homolog Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene male-specific lethal 3 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of differentially expressed proteins in ruminal epithelium in response to a concentrate-supplemented diet. Bondzio A, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Aug. PMID 21566014
    2. Gene expression profiling during increased fetal lung expansion identifies genes likely to regulate development of the distal airways. Sozo F, et al. Physiol Genomics, 2006 Jan 12. PMID 16249314
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IDH was identified as being upregulated after 2 days of dietary change.
      Title: Identification of differentially expressed proteins in ruminal epithelium in response to a concentrate-supplemented diet.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables isocitrate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    IDH
    IDP
    NADP(+)-specific ICDH
    cytosolic NADP-isocitrate dehydrogenase
    isocitrate dehydrogenase (NADP(+)) 1, cytosolic
    isocitrate dehydrogenase 1 (NADP+), soluble
    oxalosuccinate decarboxylase
    NP_001009276.1
    XP_027819687.1
    XP_042098534.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009276.1 → NP_001009276.1  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_001009276.1

      Status: PROVISIONAL

      Source sequence(s)
      AY208678
      UniProtKB/Swiss-Prot
      Q6XUZ5
      UniProtKB/TrEMBL
      W5QCD6
      Conserved Domains (1) summary
      PTZ00435
      Location:4 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      210312166..210332222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027963886.3 → XP_027819687.1  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1

      UniProtKB/TrEMBL
      W5QCD6
      Related
      ENSOARP00020021606.1, ENSOART00020026051.2
      Conserved Domains (1) summary
      PTZ00435
      Location:4 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional

    2. XM_042242600.2 → XP_042098534.1  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1

      UniProtKB/TrEMBL
      W5QCD6
      Conserved Domains (1) summary
      PTZ00435
      Location:4 → 411
      PTZ00435; isocitrate dehydrogenase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6XUZ5.1 GenPept UniProtKB/Swiss-Prot:Q6XUZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials