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    TFAP2A transcription factor AP-2 alpha [ Ovis aries (sheep) ]

    Gene ID: 443109, updated on 5-Mar-2024

    Summary

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    Gene symbol
    TFAP2A
    Gene description
    transcription factor AP-2 alpha
    See related
    EnsemblRapid:ENSOARG00020024399
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    AP2
    Orthologs
    human mouse all
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    Genomic context

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    See TFAP2A in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 20 NC_056073.1 (44826052..44848837)

    Chromosome 20 - NC_056073.1Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 2 (I blood group) Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like Neighboring gene orofacial cleft 1 candidate gene 1 protein-like Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056073.1 Chromosome 20 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel activator protein-2alpha splice-variants function as transactivators of the ovine placental lactogen gene. Limesand SW, et al. Eur J Biochem, 2001 Apr. PMID 11298758
    2. Molecular basis of estrogen-induced cyclooxygenase type 1 upregulation in endothelial cells. Gibson LL, et al. Circ Res, 2005 Mar 18. PMID 15705965
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor AP-2-alpha
    Names
    AP-2 transcription factor
    AP2-alpha
    activating enhancer-binding protein 2-alpha
    activator protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009745.1 → NP_001009745.1  transcription factor AP-2-alpha

      See identical proteins and their annotated locations for NP_001009745.1

      Status: PROVISIONAL

      Source sequence(s)
      AF260570
      UniProtKB/Swiss-Prot
      Q9N0N3, Q9N0N4, Q9N0N5
      UniProtKB/TrEMBL
      W5Q4G4
      Conserved Domains (1) summary
      pfam03299
      Location:263 → 463
      TF_AP-2; Transcription factor AP-2

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056073.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      44826052..44848837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042236730.2 → XP_042092664.1  transcription factor AP-2-alpha isoform X2

      UniProtKB/TrEMBL
      W5Q4G4
      Conserved Domains (1) summary
      pfam03299
      Location:207 → 401
      TF_AP-2; Transcription factor AP-2

    2. XM_042236731.2 → XP_042092665.1  transcription factor AP-2-alpha isoform X4

      Related
      ENSOARP00020031746.2, ENSOART00020038323.2
      Conserved Domains (1) summary
      pfam03299
      Location:174 → 368
      TF_AP-2; Transcription factor AP-2

    3. XM_027958344.3 → XP_027814145.1  transcription factor AP-2-alpha isoform X1

      UniProtKB/TrEMBL
      A0A6P7D5S1, W5Q4G4
      Related
      ENSOARP00020031704.2, ENSOART00020038278.2
      Conserved Domains (1) summary
      pfam03299
      Location:213 → 407
      TF_AP-2; Transcription factor AP-2

    4. XM_027958345.3 → XP_027814146.1  transcription factor AP-2-alpha isoform X3

      UniProtKB/TrEMBL
      W5Q4G4
      Related
      ENSOARP00020031722.1, ENSOART00020038297.2
      Conserved Domains (1) summary
      pfam03299
      Location:205 → 399
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N0N3.1 GenPept UniProtKB/Swiss-Prot:Q9N0N3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials