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    IL12A interleukin 12A [ Ovis aries (sheep) ]

    Gene ID: 443064, updated on 5-Mar-2024

    Summary

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    Gene symbol
    IL12A
    Gene description
    interleukin 12A
    See related
    EnsemblRapid:ENSOARG00020005615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    IL12; IL12P35
    Orthologs
    human mouse all
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    Genomic context

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    See IL12A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 1 NC_056054.1 (228112473..228119796, complement)

    Chromosome 1 - NC_056054.1Genomic Context describing neighboring genes Neighboring gene chromosome 1 C3orf80 homolog Neighboring gene uncharacterized LOC105611838 Neighboring gene uncharacterized LOC132658485 Neighboring gene small ribosomal subunit protein bS18m-like Neighboring gene uncharacterized LOC105603649

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056054.1 Chromosome 1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interleukin-12 p35 encoding gene of cattle and sheep harbours a polymorphic T stretch in intron 4. Schmidt P, et al. Anim Genet, 2000 Aug. PMID 11086544
    2. Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells. Swinburne SJ, et al. Cytokine, 2000 Oct. PMID 11023671
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables interleukin-12 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-12 subunit alpha
    Names
    CLMF p35
    IL-12 subunit p35
    IL-12A
    cytotoxic lymphocyte maturation factor 35 kDa subunit
    interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009736.1 → NP_001009736.1  interleukin-12 subunit alpha precursor

      See identical proteins and their annotated locations for NP_001009736.1

      Status: PROVISIONAL

      Source sequence(s)
      AF173557
      UniProtKB/Swiss-Prot
      Q9MYU0, Q9TU27
      UniProtKB/TrEMBL
      A0A836D852, W5NVX4
      Related
      ENSOARP00020007151.1, ENSOART00020008660.2
      Conserved Domains (1) summary
      pfam03039
      Location:25 → 221
      IL12; Interleukin-12 alpha subunit

    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056054.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      228112473..228119796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012146332.5 → XP_012001722.2  interleukin-12 subunit alpha isoform X1

      UniProtKB/TrEMBL
      W5NVX4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TU27.1 GenPept UniProtKB/Swiss-Prot:Q9TU27

    Gene LinkOut

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