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    SLC35A3 solute carrier family 35 member A3 [ Canis lupus familiaris (dog) ]

    Gene ID: 442991, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SLC35A3provided by VGNC
    Official Full Name
    solute carrier family 35 member A3provided by VGNC
    Primary source
    VGNC:VGNC:49650
    See related
    Ensembl:ENSCAFG00845013522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See SLC35A3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (50300428..50355335, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (52627204..52678542, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (50406295..50457631, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (49995603..50047097, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (49974502..50026207, complement)

    Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene SAS-6 centriolar assembly protein Neighboring gene uncharacterized LOC119876382 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene condensin complex subunit 1-like Neighboring gene small nucleolar RNA U3 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mammalian Golgi apparatus UDP-N-acetylglucosamine transporter: molecular cloning by phenotypic correction of a yeast mutant. Guillen E, et al. Proc Natl Acad Sci U S A, 1998 Jul 7. PMID 9653110, Free PMC Article
    2. UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate. Maszczak-Seneczko D, et al. J Biol Chem, 2013 Jul 26. PMID 23766508, Free PMC Article
    3. Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters. Maszczak-Seneczko D, et al. Acta Biochim Pol, 2011. PMID 21918738
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that UDP-N-acetylglucosamine transporter (SLC35A3) silencing reduces branching of complex N-glycans and keratan sulfate synthesis.
      Title: UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transporter
    Names
    golgi UDP-GlcNAc transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003385.1 → NP_001003385.1  UDP-N-acetylglucosamine transporter

      See identical proteins and their annotated locations for NP_001003385.1

      Status: PROVISIONAL

      Source sequence(s)
      AF057365
      UniProtKB/Swiss-Prot
      O77592
      UniProtKB/TrEMBL
      A0A8C0KGL3, A0A8C0NH00, A0A8I3NGC7
      Related
      ENSCAFP00845018964.1, ENSCAFT00845024146.1
      Conserved Domains (2) summary
      TIGR00803
      Location:86 → 313
      nst; UDP-galactose transporter
      pfam04142
      Location:1 → 314
      Nuc_sug_transp; Nucleotide-sugar transporter

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051810.1 Reference ROS_Cfam_1.0

      Range
      50300428..50355335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038667564.1 → XP_038523492.1  UDP-N-acetylglucosamine transporter isoform X2

      UniProtKB/TrEMBL
      A0A8C0KF53, A0A8C0NLG7, A0A8P0T180
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 296
      Nuc_sug_transp; Nucleotide-sugar transporter

    2. XM_038667565.1 → XP_038523493.1  UDP-N-acetylglucosamine transporter isoform X2

      UniProtKB/TrEMBL
      A0A8C0KF53, A0A8C0NLG7, A0A8P0T180
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 296
      Nuc_sug_transp; Nucleotide-sugar transporter

    3. XM_038667567.1 → XP_038523495.1  UDP-N-acetylglucosamine transporter isoform X2

      UniProtKB/TrEMBL
      A0A8C0KF53, A0A8C0NLG7, A0A8P0T180
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 296
      Nuc_sug_transp; Nucleotide-sugar transporter

    4. XM_038667568.1 → XP_038523496.1  UDP-N-acetylglucosamine transporter isoform X2

      UniProtKB/TrEMBL
      A0A8C0KF53, A0A8C0NLG7, A0A8P0T180
      Conserved Domains (1) summary
      pfam04142
      Location:1 → 296
      Nuc_sug_transp; Nucleotide-sugar transporter

    5. XM_038667563.1 → XP_038523491.1  UDP-N-acetylglucosamine transporter isoform X1

      UniProtKB/TrEMBL
      A0A8C0KF53
      Conserved Domains (1) summary
      pfam04142
      Location:18 → 313
      Nuc_sug_transp; Nucleotide-sugar transporter

    6. XM_038667569.1 → XP_038523497.1  UDP-N-acetylglucosamine transporter isoform X3

      UniProtKB/TrEMBL
      A0A8C0NH00, A0A8I3NGC7
      Related
      ENSCAFP00845018952.1, ENSCAFT00845024127.1
      Conserved Domains (1) summary
      pfam04142
      Location:18 → 331
      Nuc_sug_transp; Nucleotide-sugar transporter

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049266.1 Alternate UMICH_Zoey_3.1

      Range
      49995603..50047097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

      Range
      49974502..50026207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

      Range
      50406295..50457631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      52627204..52678542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77592.1 GenPept UniProtKB/Swiss-Prot:O77592

    Gene LinkOut

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