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    ZFAS1 ZNFX1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 441951, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZFAS1provided by HGNC
    Official Full Name
    ZNFX1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:33101
    See related
    Ensembl:ENSG00000177410 AllianceGenome:HGNC:33101
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSUP1; HSUP2; C20orf199; ZNFX1-AS1; NCRNA00275
    Summary
    This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 66.8), bone marrow (RPKM 54.6) and 24 other tissues See more
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    Genomic context

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    See ZFAS1 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (49278178..49289260)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (51047676..51058760)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47894715..47905797)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47835541-47836266 Neighboring gene DEAD-box helicase 27 Neighboring gene zinc finger NFX1-type containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18057 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47894170-47894670 Neighboring gene Sharpr-MPRA regulatory region 13855 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:47900044-47900976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47902841-47903772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47903773-47904704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18060 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47909763-47910696 Neighboring gene small nucleolar RNA, C/D box 12C Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:47910697-47911630 Neighboring gene small nucleolar RNA, C/D box 12B Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47911631-47912563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47913664-47914226 Neighboring gene small nucleolar RNA, C/D box 12 Neighboring gene uncharacterized LOC124904925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47934991-47935572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47935573-47936154 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47940265-47940766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:47940767-47941266 Neighboring gene uncharacterized LOC105372649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18061 Neighboring gene NANOG hESC enhancer GRCh37_chr20:47985158-47985711 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:47990213-47990475 Neighboring gene potassium voltage-gated channel subfamily B member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48040793-48041316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48041317-48041840

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA zinc finger antisense 1 expression associates with increased disease risk, elevated disease severity and higher inflammatory cytokines levels in patients with lumbar disc degeneration. Deng RY, et al. Medicine (Baltimore), 2019 Dec. PMID 31876730, Free PMC Article
    2. Long non-coding RNA ZFAS1 sponges miR-486 to promote osteosarcoma cells progression and metastasis in vitro and vivo. Li N, et al. Oncotarget, 2017 Nov 28. PMID 29262629, Free PMC Article
    3. Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/β-catenin signaling in gastric cancer cells. Xu W, et al. Biosci Biotechnol Biochem, 2018 Mar. PMID 29424266
    4. Long non-coding RNA ZFAS1 promotes colorectal cancer tumorigenesis and development through DDX21-POLR1B regulatory axis. Wang X, et al. Aging (Albany NY), 2020 Nov 16. PMID 33202381, Free PMC Article
    5. Downregulation of the long non-coding RNA ZFAS1 is associated with cell proliferation, migration and invasion in breast cancer. Fan S, et al. Mol Med Rep, 2018 May. PMID 29532866, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA ZFAS1 Alleviated NLRP3 Inflammasome-Mediated Pyroptosis through Regulating miR-96-5p/Smad7 Signaling in Allergic Rhinitis.
      Title: LncRNA ZFAS1 Alleviated NLRP3 Inflammasome-Mediated Pyroptosis through Regulating miR-96-5p/Smad7 Signaling in Allergic Rhinitis.
    2. Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
      Title: Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
    3. LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
      Title: LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
    4. Long noncoding RNA ZFAS1: A novel anti-apoptotic target in Fuchs endothelial corneal dystrophy.
      Title: Long noncoding RNA ZFAS1: A novel anti-apoptotic target in Fuchs endothelial corneal dystrophy.
    5. p53-associated miRNAs repress lncRNA ZFAS1 to retard the proliferation of papillary thyroid carcinoma.
      Title: p53-associated miRNAs repress lncRNA ZFAS1 to retard the proliferation of papillary thyroid carcinoma.
    6. The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis.
      Title: The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis.
    7. LncRNA ZFAS1 promotes laryngeal cancer progression through RBFOX2-mediated MENA alternative splicing.
      Title: LncRNA ZFAS1 promotes laryngeal cancer progression through RBFOX2-mediated MENA alternative splicing.
    8. LncRNA ZFAS1 ameliorates injury led by non-alcoholic fatty liver disease via suppressing lipid peroxidation and inflammation.
      Title: LncRNA ZFAS1 ameliorates injury led by non-alcoholic fatty liver disease via suppressing lipid peroxidation and inflammation.
    9. LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling.
      Title: LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling.
    10. Clinical significance and biological effect of ZFAS1 in Hirschsprung's disease and preliminary exploration of its underlying mechanisms using integrated bioinformatics analysis.
      Title: Clinical significance and biological effect of ZFAS1 in Hirschsprung's disease and preliminary exploration of its underlying mechanisms using integrated bioinformatics analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (81)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ZNFX1 antisense RNA 1 (non-protein coding)
    • ZNFX1 antisense gene protein 1

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003604.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL049766
      Related
      ENST00000450535.5

    2. NR_003605.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at the 5' end and is shorter, compared to variant 1.
      Source sequence(s)
      AL049766
      Related
      ENST00000458653.6

    3. NR_003606.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal exons and is shorter, compared to variant 1.
      Source sequence(s)
      AL049766
      Related
      ENST00000417721.6

    4. NR_036658.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon and is shorter, compared to variant 1.
      Source sequence(s)
      AL049766

    5. NR_036659.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal exon and uses an alternate 5' exon compared to variant 1.
      Source sequence(s)
      AL049766
      Related
      ENST00000326677.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      49278178..49289260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      51047676..51058760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials