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    Optix optix [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44108, updated on 18-Sep-2024

    Summary

    Official Symbol
    Optixprovided by FlyBase
    Official Full Name
    optixprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025360
    Locus tag
    Dmel_CG18455
    See related
    AllianceGenome:FB:FBgn0025360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.79; CG18455; D-Six3; Dmel\CG18455; Dsix3; opt; optix; OPTIX; opx; six3; Six3
    Summary
    Enables sequence-specific DNA binding activity. Involved in compound eye photoreceptor cell differentiation; dendrite morphogenesis; and progression of morphogenetic furrow involved in compound eye morphogenesis. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; extended germ band embryo; head; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in holoprosencephaly; holoprosencephaly 2; and optic disc anomalies with retinal and/or macular dystrophy. Orthologous to human SIX3 (SIX homeobox 3) and SIX6 (SIX homeobox 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Optix in Genome Data Viewer
    Location:
    44A3-44A3; 2-58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8031283..8042529)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3918788..3930034)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45267 Neighboring gene long non-coding RNA:CR43724 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    optix
    Names
    CG18455-PA
    CG18455-PB
    CG18455-PC
    Optix-PA
    Optix-PB
    Optix-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8031283..8042529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273864.2NP_001260793.1  optix, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEE9
      Conserved Domains (2) summary
      cd00086
      Location:158206
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:37150
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
    2. NM_079956.3NP_524695.2  optix, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524695.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76291, Q8MKN3, Q95RW8, Q9UA64, Q9V355
      Related
      FBpp0087941
      Conserved Domains (2) summary
      cd00086
      Location:158206
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:37150
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
    3. NM_165584.2NP_724640.1  optix, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RW8
      Related
      FBpp0087942