wit wishful thinking [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: witprovided by FlyBase
Official Full Name: wishful thinkingprovided by FlyBase
Primary source: FLYBASE:FBgn0024179
Locus tag: Dmel_CG10776
See related: AllianceGenome:FB:FBgn0024179
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1262/15; ALK3/BMPRII; BMP; CG10776; Dmel\CG10776; l(3)64Aa; l(3)S126215; l(3)SH12; SE20; Stk-D; STK-D; Wit; WIT; Wit-C; wiw
Summary: Enables BMP receptor activity and activin receptor activity, type II. Contributes to BMP binding activity. Involved in several processes, including positive regulation of SMAD protein signal transduction; positive regulation of synaptic assembly at neuromuscular junction; and transforming growth factor beta receptor superfamily signaling pathway. Located in early endosome; recycling endosome; and synapse. Part of BMP receptor complex; activin receptor complex; and trans-synaptic protein complex. Is active in apical plasma membrane. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval midgut; ganglia; and larval neurons. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease 1. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 64A5-64A5; 3-10 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4064152..4071717, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4064152..4071717, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gef26-Rap1 signaling pathway regulates both synaptic growth and neuronal survival by controlling BMP signaling.
Title: The Rap activator Gef26 regulates synaptic growth and neuronal survival via inhibition of BMP signaling.
In locus analysis of patterning evolution of the BMP type II receptor Wishful thinking.
Title: In locus analysis of patterning evolution of the BMP type II receptor Wishful thinking.
Wit interaction with Dnrx/Dnlg1 coordinates synaptic growth and architecture at the NMJ.
Title: Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions.
data suggests that during oogenesis WIT acts as a type II receptor to regulate follicle cell patterning and morphogenesis of the eggshell
Title: The Drosophila BMPRII, wishful thinking, is required for eggshell patterning.
Wit globally regulates NMJ function by controlling both the growth and transmitter release properties of the synapse.
Title: Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila.
Results suggest that Wishful thinking binds multiple ligands to activate both bone morphogenetic protein and transforming growth factor-beta-like signaling pathways, and may mediate myoglianin-dependent signals in the nervous system.
Title: The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type II	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of BMP receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of activin receptor complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of trans-synaptic protein complex	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: wishful thinking

Names: CG10776-PA; CG10776-PB; Serine/threonine kinase-D; bone morphogenetic protein; wit-PA; wit-PB

NP_001261395.1

EC 2.7.11.30

NP_524692.3

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4064152..4071717 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079953.4 → NP_524692.3 wishful thinking, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524692.3

Status: REVIEWED

UniProtKB/TrEMBL

Q95V83, Q9VZI9

Related

FBpp0073135

Conserved Domains (3) summary

smart00221
Location:226 → 517

STYKc; Protein kinase; unclassified specificity

cl11586
Location:57 → 133

snake_toxin; Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and ...

cd14054
Location:228 → 528

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors
NM_001274466.1 → NP_001261395.1 wishful thinking, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261395.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE88, Q95V83

Conserved Domains (3) summary

smart00221
Location:226 → 517

STYKc; Protein kinase; unclassified specificity

cl11586
Location:57 → 133

snake_toxin; Snake toxin domain, present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and ...

cd14054
Location:228 → 528

STKc_BMPR2_AMHR2; Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors