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    sesn1 sestrin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 436933, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sesn1provided by ZNC
    Official Full Name
    sestrin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-408
    See related
    Ensembl:ENSDARG00000020693 AllianceGenome:ZFIN:ZDB-GENE-040718-408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91970; zgc:103669; si:ch211-51a19.4
    Summary
    Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Acts upstream of or within determination of left/right symmetry. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including anterior axial hypoblast; central nervous system; mandibular arch skeleton; mesoderm; and pronephros. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sesn1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (32152387..32230287)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (32249493..32327408)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene CD164 molecule, sialomucin Neighboring gene centrosomal protein 57, like 1 Neighboring gene si:ch211-51a19.5 Neighboring gene armadillo repeat containing 2 Neighboring gene forkhead box O3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway. Wu J, et al. Hum Genomics, 2019 Dec 5. PMID 31806011, Free PMC Article
    2. p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Ye S, et al. Cell Death Dis, 2020 Jul 23. PMID 32703938, Free PMC Article
    3. Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling. Peeters H, et al. Hum Mol Genet, 2006 Nov 15. PMID 17038485
    4. Early embryonic gene expression profiling of zebrafish prion protein (Prp2) morphants. Nourizadeh-Lillabadi R, et al. PLoS One, 2010 Oct 22. PMID 21042590, Free PMC Article
    5. Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Zhao T, et al. Cell Death Dis, 2021 Feb 4. PMID 33542214, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-leucine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to leucine starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sestrin-1
    Names
    WITHDRAWN: zgc:103669
    NP_001002660.1
    XP_005160727.1
    XP_005160728.1
    XP_005160730.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002660.1 → NP_001002660.1  sestrin-1

      See identical proteins and their annotated locations for NP_001002660.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076550
      UniProtKB/TrEMBL
      A0F080, Q6DG05
      Related
      ENSDARP00000062992.4, ENSDART00000062993.6
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 487
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      32152387..32230287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160670.5 → XP_005160727.1  sestrin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7J7
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 557
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_005160671.5 → XP_005160728.1  sestrin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7J2, U3JAG5
      Related
      ENSDARP00000127233.1, ENSDART00000152904.3
      Conserved Domains (1) summary
      pfam04636
      Location:106 → 546
      PA26; PA26 p53-induced protein (sestrin)

    3. XM_005160673.5 → XP_005160730.1  sestrin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B7S8, Q5RGN4
      Related
      ENSDARP00000120221.1, ENSDART00000147448.2
      Conserved Domains (1) summary
      pfam04636
      Location:47 → 498
      PA26; PA26 p53-induced protein (sestrin)
    Nucleotide Protein Strain
    Heading Accession and Version

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