dusp22a dual specificity phosphatase 22a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dusp22aprovided by ZNC
Official Full Name: dual specificity phosphatase 22aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-219
See related: Ensembl:ENSDARG00000056396 AllianceGenome:ZFIN:ZDB-GENE-040718-219
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dusp22; zgc:92816; wu:fa11e09
Summary: Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in positive regulation of JNK cascade; regulation of cell population proliferation; and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Orthologous to human DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (30511229..30564688)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (30532975..30586434)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk29f10.y1 (e-PCR)
- UniSTS:200766

fa11e09.s1 (e-PCR)
- UniSTS:202313

AA494835 (e-PCR)
- UniSTS:186837

AI106200 (e-PCR)
- UniSTS:206842

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity protein phosphatase 22-A

NP_001002514.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002514.1 → NP_001002514.1 dual specificity protein phosphatase 22-A

See identical proteins and their annotated locations for NP_001002514.1

Status: PROVISIONAL

Source sequence(s)

BC076284

UniProtKB/Swiss-Prot

Q1LWL2, Q6DGQ6

Related

ENSDARP00000073347.4, ENSDART00000078888.5

Conserved Domains (1) summary

cd00127
Location:4 → 139

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...