nkx6.1 NK6 homeobox 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nkx6.1provided by ZNC
Official Full Name: NK6 homeobox 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-178
See related: Ensembl:ENSDARG00000022569 AllianceGenome:ZFIN:ZDB-GENE-040718-178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92879
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (19070921..19073831)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (19034285..19037195)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.
Title: Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells.
Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a interneuron-like morphology.
Title: Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression.
In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons
Title: Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreatic A cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreatic A cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type B pancreatic cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within type B pancreatic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Nkx-6.1

Names: NK6 transcription factor related, locus 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.