arr3a arrestin 3a, retinal (X-arrestin) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arr3aprovided by ZNC
Official Full Name: arrestin 3a, retinal (X-arrestin)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-102
See related: Ensembl:ENSDARG00000056511 AllianceGenome:ZFIN:ZDB-GENE-040718-102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: arr3l; zgc:92697; c-arrestin
Summary: Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within visual perception. Is expressed in epiphysis and retina. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (26800215..26811397)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (26838502..26849684)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show subfunctionalized expression of Arr3a in M- and L-cones, and Arr3b in S- and UV-cones, and suggest that Arr3a deficiency is sufficient to reduce temporal contrast sensitivity.
Title: Cone arrestin confers cone vision of high temporal resolution in zebrafish larvae.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: arrestin 3a, retinal (X-arrestin)

Names: arrestin 3, retinal (X-arrestin), like; cone arrestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002405.1 → NP_001002405.1 arrestin 3a, retinal (X-arrestin)

See identical proteins and their annotated locations for NP_001002405.1

Status: PROVISIONAL

Source sequence(s)

BC076177

UniProtKB/TrEMBL

A0A8M1N0I0, Q6DH07

Related

ENSDARP00000073453.4, ENSDART00000078996.5

Conserved Domains (2) summary

smart01017
Location:192 → 355

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:36 → 173

Arrestin_N; Arrestin (or S-antigen), N-terminal domain