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    PH4alphaNE1 prolyl-4-hydroxylase-alpha NE1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43625, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PH4alphaNE1provided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha NE1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039780
    Locus tag
    Dmel_CG9728
    See related
    AllianceGenome:FB:FBgn0039780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9728; Dmel\CG9728
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in myopia. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1); P4HA2 (prolyl 4-hydroxylase subunit alpha 2); and P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PH4alphaNE1 in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30496751..30500326, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26322473..26326048, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene prolyl-4-hydroxylase-alpha MP Neighboring gene uncharacterized protein Neighboring gene prolyl-4-hydroxylase-alpha SG1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    2. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497
    3. Gene Expression Associated with Early and Late Chronotypes in Drosophila melanogaster. Pegoraro M, et al. Front Neurol, 2015. PMID 26097463, Free PMC Article
    4. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolyl-4-hydroxylase-alpha NE1
    Names
    CG9728-PA
    PH4alphaNE1-PA
    NP_733374.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30496751..30500326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170495.2 → NP_733374.1  prolyl-4-hydroxylase-alpha NE1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL2, Q9VA64
      Related
      FBpp0085050
      Conserved Domains (2) summary
      smart00702
      Location:341 → 511
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:26 → 155
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0N6 Q8T0N6
    Q8T5S6 Q8T5S6
    Q9VA64 Q9VA64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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