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    PH4alphaMP prolyl-4-hydroxylase-alpha MP [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43624, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PH4alphaMPprovided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha MPprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026190
    Locus tag
    Dmel_CG9726
    See related
    AllianceGenome:FB:FBgn0026190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    59D7T; CG9726; DM59D7T; Dmel\CG9726; ESTS:59D7T
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PH4alphaMP in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30491813..30496153, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26317535..26321875, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Fii Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene prolyl-4-hydroxylase-alpha NE1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the alpha subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties. Annunen P, et al. J Biol Chem, 1999 Mar 5. PMID 10037780
    2. The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits. Myllyharju J, et al. J Biol Chem, 2002 Aug 9. PMID 12036960
    3. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    4. One-hundred and five new potential Drosophila melanogaster genes revealed through STS analysis. Louis C, et al. Gene, 1997 Aug 22. PMID 9305763
    5. Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2. Abrams EW, et al. Development, 2006 Sep. PMID 16914497

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster
      Title: Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolyl-4-hydroxylase-alpha MP
    Names
    CG9726-PA
    PH4alphaMP-PA
    alpha subunit
    prolyl-4-hydroxylase-alpha
    NP_524594.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30491813..30496153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079855.3 → NP_524594.2  prolyl-4-hydroxylase-alpha MP [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524594.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97126, Q9VA65
      Related
      FBpp0085051
      Conserved Domains (2) summary
      smart00702
      Location:336 → 509
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:24 → 156
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97126 O97126
    Q9VA65 Q9VA65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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