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    CecA1 Cecropin A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43596, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CecA1provided by FlyBase
    Official Full Name
    Cecropin A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000276
    Locus tag
    Dmel_CG1365
    See related
    AllianceGenome:FB:FBgn0000276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ce-A1; cec; Cec; CEC; cec A; Cec A1; Cec-A1; cecA; CecA; cecA1; CecA2; cecropin; CG1365; crpA1; DIM 25; Dmel\CG1365
    Summary
    Involved in defense response to other organism. Located in extracellular space. Is expressed in adult anterior midgut; embryonic/larval circulatory system; epithelium; fat body; and yolk. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CecA1 in Genome Data Viewer
    Location:
    99E2-99E2; 3-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30210874..30211273)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26036596..26036995)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S7 Neighboring gene ncRNA Neighboring gene Andropin Neighboring gene Cecropin pseudogene 1 Neighboring gene Cecropin A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and characterization of the antibacterial activity of a novel hybrid antimicrobial peptide comprising functional domains from different insect cecropins. Plunkett RM, et al. Can J Microbiol, 2009 May. PMID 19483780
    2. Antimicrobial peptides extend lifespan in Drosophila. Loch G, et al. PLoS One, 2017. PMID 28520752, Free PMC Article
    3. Activation of an innate immune response in large numbers of permeabilized Drosophila embryos. Esfahani SS, et al. Dev Comp Immunol, 2011 Mar. PMID 21075135
    4. Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans. Boulanger N, et al. J Biol Chem, 2002 Dec 20. PMID 12372834
    5. A humoral stress response in Drosophila. Ekengren S, et al. Curr Biol, 2001 Sep 18. PMID 11566110

    See all (383) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that in response to infection Drosophila egg expressed several immune genes including AttacinA (CG10146), CecropinA1 (CG1365) and CecropinB (CG1878).
      Title: Immune competence in insect eggs depends on the extraembryonic serosa.
    2. The functionality of CecA1 ARE relies on its ability to recruit TIS11 protein, which accelerates CecA1 mRNA deadenylation and decay
      Title: Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila.
    3. high levels of CecA1 antimicrobial peptide gene expression in response to infection
      Title: Functional characterization of a novel promoter element required for an innate immune response in Drosophila.
    4. Gene was induced by the G(+) bacteria Micrococcus luteus and Staphylococcus aureus, but not by other G(+) or G(-) bacteria.
      Title: Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibacterial humoral response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to virus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in humoral immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to bacterium HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cecropin A1
    Names
    CG1365-PA
    CecA1-PA
    Cecropin-A1/A2 precursor
    CecropinA
    cecropin
    cecropin A
    cecropin-A
    cecropin-A1
    cecropinA1
    cecropins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30210874..30211273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079849.4 → NP_524588.1  cecropin A1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DN02, B3DN08, C0HKQ7, C0HKQ8, O16815, O16816, O16817, O16818, O16819, O16820, O16821, O61275, O61276, O61277, O61279, O62590, P14954, P82449
      Related
      FBpp0084977
      Conserved Domains (1) summary
      pfam00272
      Location:28 → 61
      Cecropin; Cecropin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HKQ7.1 C0HKQ7
    C0HKQ8.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials