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    Nom1 nucleolar protein with MIF4G domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 433864, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nom1provided by MGI
    Official Full Name
    nucleolar protein with MIF4G domain 1provided by MGI
    Primary source
    MGI:MGI:1861749
    See related
    Ensembl:ENSMUSG00000001569 AllianceGenome:MGI:1861749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Kng1; Gm1040
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within hair follicle maturation. Predicted to be active in nucleolus. Is expressed in several structures, including bladder; dorsal root ganglion; limb; skeleton; and ventral grey horn. Orthologous to human NOM1 (nucleolar protein with MIF4G domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.8), liver E14 (RPKM 6.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nom1 in Genome Data Viewer
    Location:
    5 B1; 5 15.0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29637338..29658504)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29434659..29452169)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene limb region 1 Neighboring gene STARR-seq mESC enhancer starr_12732 Neighboring gene STARR-seq mESC enhancer starr_12733 Neighboring gene zone of polarising activity regulatory sequence 1 Neighboring gene STARR-seq mESC enhancer starr_12734 Neighboring gene STARR-positive B cell enhancer ABC_E9634 Neighboring gene predicted gene, 36086 Neighboring gene STARR-positive B cell enhancer ABC_E9252 Neighboring gene predicted gene, 24538 Neighboring gene motor neuron and pancreas homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Symmons O, et al. Dev Cell, 2016 Dec 5. PMID 27867070, Free PMC Article
    2. Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription. Amano T, et al. Dev Cell, 2009 Jan. PMID 19097946
    3. Mapping the Shh long-range regulatory domain. Anderson E, et al. Development, 2014 Oct. PMID 25252942, Free PMC Article
    4. A novel candidate gene for mouse and human preaxial polydactyly with altered expression in limbs of Hemimelic extra-toes mutant mice. Clark RM, et al. Genomics, 2000 Jul 1. PMID 10945466
    5. Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. DiTommaso T, et al. PLoS Genet, 2014 Oct. PMID 25340873, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hair follicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar MIF4G domain-containing protein 1
    Names
    SGD1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033457.2 → NP_001028629.2  nucleolar MIF4G domain-containing protein 1

      See identical proteins and their annotated locations for NP_001028629.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      AC171500, AK148406
      Consensus CDS
      CCDS19149.1
      UniProtKB/Swiss-Prot
      E9QPB9, Q3UFM5
      Related
      ENSMUSP00000001611.10, ENSMUST00000001611.11
      Conserved Domains (2) summary
      smart00543
      Location:357 → 553
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      cl02653
      Location:649 → 755
      MA3; MA3 domain

    RNA

    1. NR_153385.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon and contains another alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC171500

    2. NR_153386.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC171500

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      29637338..29658504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535742.4 → XP_006535805.1  nucleolar MIF4G domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      smart00543
      Location:357 → 553
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam07263
      Location:255 → 332
      DMP1; Dentin matrix protein 1 (DMP1)
      cl02653
      Location:649 → 755
      MA3; MA3 domain

    2. XM_011249776.3 → XP_011248078.1  nucleolar MIF4G domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      smart00543
      Location:357 → 553
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam07263
      Location:255 → 332
      DMP1; Dentin matrix protein 1 (DMP1)
      cl02653
      Location:649 → 755
      MA3; MA3 domain

    RNA

    1. XR_001784716.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UFM5.2 GenPept UniProtKB/Swiss-Prot:Q3UFM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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