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    Clbn Caliban [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43018, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Clbnprovided by FlyBase
    Official Full Name
    Calibanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259152
    Locus tag
    Dmel_CG11847
    See related
    AllianceGenome:FB:FBgn0259152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11847; clbn; Dmel\CG11847; NEMF
    Summary
    Enables tRNA binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; protein export from nucleus; and rescue of stalled ribosome. Located in cytoplasmic side of mitochondrial outer membrane. Is expressed in adult head. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Clbn in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25127502..25131155)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20953224..20956877)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene vig2 Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A Neighboring gene Band4.1 inhibitor LRP interactor Neighboring gene long non-coding RNA:CR46098

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity. Wang Y, et al. Oncogene, 2013 Aug 15. PMID 22964637
    2. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Bi X, et al. Oncogene, 2005 Dec 15. PMID 16103875
    3. Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint. Song F, et al. Cell Cycle, 2018. PMID 30231800, Free PMC Article
    4. Birth of a new gene on the Y chromosome of Drosophila melanogaster. Carvalho AB, et al. Proc Natl Acad Sci U S A, 2015 Oct 6. PMID 26385968, Free PMC Article
    5. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Rimal S, et al. Acta Neuropathol Commun, 2021 Oct 18. PMID 34663454, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes.
      Title: Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes.
    2. Induced expression of clbn suppressed E2F1 activity and down-regulates the DNA replication and expression of its downstream target cyclin E, a key regulator of G1-to-S transition.
      Title: Drosophila Caliban mediates G1-S transition and ionizing radiation induced S phase checkpoint.
    3. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways.
      Title: The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.
    4. Expression of fly caliban in human lung cancer cells restores non-functional nuclear export of lung cancer cells, impairs a cell's ability to form colonies on soft agar and reduces cell invasiveness
      Title: Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAT tailing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caliban
    Names
    CG11847-PB
    CG11847-PC
    Clbn-PB
    Clbn-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25127502..25131155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143084.2 → NP_651341.2  caliban, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651341.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6Q0, Q9VBX1
      UniProtKB/TrEMBL
      D2NUI9
      Conserved Domains (3) summary
      COG1293
      Location:1 → 643
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
      pfam05670
      Location:531 → 630
      DUF814; Domain of unknown function (DUF814)
      pfam11923
      Location:883 → 984
      DUF3441; Domain of unknown function (DUF3441)

    2. NM_001170250.1 → NP_001163721.1  caliban, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6Q0, Q9VBX1
      UniProtKB/TrEMBL
      D2NUI9
      Conserved Domains (3) summary
      COG1293
      Location:1 → 643
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
      pfam05670
      Location:531 → 630
      DUF814; Domain of unknown function (DUF814)
      pfam11923
      Location:883 → 984
      DUF3441; Domain of unknown function (DUF3441)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBX1.2 Q9VBX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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